黄芪对脑缺血再灌流损伤保护作用的实验研究  

The Experimental Research of Huang qi′s Protection on Cerebral Ischemia-Reperfusion Injyry

作　　者：陈春富[1] 郭述苏[1] 王红梅[1] 王和德[1] 

机构地区：[1]济南军区总医院,250031 [2]济南市第四人民医院

出　　处：《河北中医药学报》1999年第3期1-3,共3页Journal of Hebei Traditional Chinese Medicine and Pharmacology

摘　　要：用大鼠局灶性脑缺血再灌流和全脑缺血再灌流损伤两种动物模型 ,观察黄芪注射液对脑缺血后再灌流期间血脑屏障及脑血流的保护作用。结果显示 ,与相应对照组比较 ,不论是全脑缺血还是局灶性脑缺血 1h后再灌流 3h,应用黄芪的各组动物脑水肿明显减轻 ,血脑屏障通透性改善 ,大脑局部血流量显著增加。提示黄芪对脑缺血后脑水肿、血脑屏障、大脑局部血流量具有保护作用。Two kinds of animal models including rat′s focal cerebral ischemia-reperfusion injury and whole cerebral-ischemia-reperfusion injury were used to observe Huang qi injection′s protection on BBB and CBF during the period of cerebral ischemia reperfusion.The result showed that,compared with the control group,both the whole and focal cerebral ischemia,the animal′s cerebral edema in Huang qi group was obviously eased,the animal′s permeability of BBB was improved and the animal′s local CBF was remarkably iscreased by three-hour reperfusion after one-hour cerebral ischemia,which suggested that Huang qi could protect cerebral edema,BBB and local CBF.

关 键 词：黄芪 脑缺血 再灌流损伤 血脑屏障 

分 类 号：R282.710.5[医药卫生—中药学] R277.733.1[医药卫生—中医学]