大蒜素注射液治疗急性脑梗死101例临床研究  

Clinical studies on treatment with galic injection for 101 patients with acutely cerebral infarction

作　　者：史载祥[1] 张久亮[1] 毛建生[1] 刘爱华[2] 自伯海[3] 石义亭[3] 魏青 李海聪[1] 杜金行[1] 黄力[1] 曹启富[1] 

机构地区：[1]北京中日友好医院中医心肾科,北京100029 [2]北京宣武医院,北京100050 [3]山东省滕州市中心人民医院,山东滕州277500 [4]北京顺义县中医院,北京顺义101300

出　　处：《中国中西医结合急救杂志》1999年第9期390-394,共5页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：国家自然科学基金

摘　　要：目的：探讨大蒜素注射液治疗急性脑梗死的疗效及作用机制。方法：１５４ 例急性脑梗死患者随机分为２ 组。大蒜素组采用大蒜素注射液６０ ｍ ｇ 加５％ 葡萄糖５００ ｍ ｌ静滴，川芎嗪组采用川芎嗪注射液８０ ｍ ｇ 加５％葡萄糖５００ ｍ ｌ静滴，均每日１ 次，２ 周为１ 个疗程。此外，２ 组均给予对症治疗，观察疗效，并检测丙二醛（ＭＤＡ）含量、血液流变性、白细胞流变性、脑血流量等指标，并与正常人作比较。结果：治疗２ 周时，大蒜素组总有效率（７７２３％ ）显著高于川芎嗪组（６２２６％ ，Ｐ＜ ００５）；治疗２ 周及４ 周后，大蒜素组神经功能缺损评分减少和神经功能改善均优于川芎嗪组。急性脑梗死患者血清ＭＤＡ 含量较正常对照组明显升高（Ｐ＜ ００１）；治疗３周时，大蒜素组ＭＤＡ含量较川芎嗪组明显降低（Ｐ＜ ００１）。大蒜素注射液还可明显改善急性脑梗死患者的白细胞滤过指数、血液流变学及脑血流指标。结论：大蒜素注射液在改善血液流变性、增加脑血流量的同时，又可清除自由基，改善脑功能，减轻急性脑梗死时缺血 再灌注损伤；Objective:To investigate the curative effects of galic injection on acutely cerebral infarction(ACI) and its mechanisms.Methods:154 cases with ACI were randomly divided into two groups.The galic group was treated with galic injection 60 mg+5% glucose 500 ml infused intravenously but the tetramethylpyrazine group treated with tetramethylpyrazine injection 80 mg+5% glucose 500 ml infused intravenously once a day for two weeks as a therapeutic course in both two groups.Otherwise the symptomatic therapy was used simultaneously.The curative effects were observed,the concentration of malondialdehyde(MDA) and the parameters of blood rheology,white blood cell(WBC) rheology,and volume of cerebral blood flow were measured and compared to normal subjects.Results:By the end of twoweek therapy the total effective rate (77 23%) in galic group was significantly higher than that (62 26%) in tetramethylpyrazine group( P <0 05).After two weeks and four weeks therapy the decrease in scores of nervous functional defects and the improvement of nervous functions in galic group were superior to those in tetramethylpyrazine group.The level of serum MDA in patients with ACI was significantly higher than that in normal subjects ( P <0 01).In the time of threeweek therapy the concentration of MDA in galic group was significantly lower than that in tetramethylpyrazine group( P <0 01).The galic injection was also able to improve the filterable index of WBC,parameters of blood rheology,and cerebral blood flow.Conclusions:The galic injection can improve the blood rheology and increase the volume of cerebral blood flow at the same time it is able to eliminate oxygen free radicals,improve cerebral functions,and relieve ischemiareperfusion damage in ACI so that it can be used to treat ACI and curative effects are superior to those of tetramethylpyrazine injection.

关 键 词：脑梗死 急性 大蒜素注射液 血液流变性 

分 类 号：R931.71[医药卫生—生药学] R743.330.5[医药卫生—药学]