亚临床甲状腺功能减退与冠心病关系的Meta分析  

A Meta-analysis on Relationship between Subclinical Hypothyroidism and Coronary Heart Disease

作　　者：张娜[1] 张文良[1] 时景璞[1] 

机构地区：[1]中国医科大学附属第一医院临床流行病教研室,辽宁省沈阳市110001

出　　处：《中国全科医学》2011年第2期125-129,共5页Chinese General Practice

摘　　要：目的探讨亚临床甲状腺功能减退与冠心病的相关性。方法检索1996—2010年4月发表的关于亚临床甲状腺功能减退与冠心病关系的前瞻性研究文献,提取相关数据并应用Stata11.0软件进行统计分析。结果共纳入相关文献11篇(累积样本量15 577例),显示亚临床甲状腺功能减退对冠心病的作用合并RR值为1.12[95%CI(0.99,1.28)],无统计学意义(P>0.05)。对亚组分析发现,跟踪时间>5年组、平均年龄<60岁组、亚洲人群和促甲状腺激素(TSH)≥7 mU/L组亚临床甲状腺功能减退是冠心病的危险因素,合并RR值分别为1.19[95%CI(1.03,1.38)],1.54[95%CI(1.16,2.04)]和1.57[95%CI(1.01,2.43)]。结论亚临床甲状腺功能减退对冠心病的发生可能是长期的潜在作用,主要影响年龄<60岁的人群和亚洲人群,且随亚临床甲状腺功能减退者的TSH水平增高患冠心病的风险增大。Objective To determine the association between subclinical hypothyroidism and coronary heart disease（CHD）.Methods We searched for the studies which provided risk estimates for CHD associated with Subclinical Hypothyroidism,extracted the data and conducted the statistical analysis using Stata 11.0 software.Results 11 studies were involved totally.The total pooling RR was 1.12,RR,while it shows no statistic significance for the association between subclinical hypothyroidism and CHD.Subgroup analyses shows that subclinical hypothyroidism increased the risk of CHD with studies that more than 5 years follows up,that younger mean ages（60）,that Asia people and that TSH levels≥7mIU/L.Conclusion The results suggested that subclinical hypothyroidism might be a potentially risk factor for CHD.Those whose ages60 and Asia people with SCH have a increased risk of CHD,and the greater the TSH levels become,the greater risk of CHD events.

关 键 词：亚临床甲状腺功能减退 冠心病 META分析 前瞻性研究 

分 类 号：R581.9[医药卫生—内分泌] R541.4[医药卫生—内科学]