甲泼尼龙辅助治疗难治性支原体肺炎疗效观察  

Methylprednisolone in Adjunctive Treatment of Refractory Mycoplasma Pneumonia

作　　者：邵晓丽[1] 刘淑梅[1] 楼文勇[1] 朱国政[1] 

机构地区：[1]浙江省绍兴市人民医院儿科,312000

出　　处：《中国全科医学》2011年第2期186-187,共2页Chinese General Practice

基　　金：绍兴市社会发展重点科研项目(2008A23003)

摘　　要：目的探讨甲泼尼龙辅助治疗难治性支原体肺炎的临床疗效。方法选取2008—2010年我科住院的76例难治性支原体肺炎患儿,随机分为对照组和治疗组,对照组抗生素治疗,治疗组在抗生素治疗的基础上加用小剂量甲泼尼龙,比较两组咳嗽缓解时间、体温恢复时间、住院时间、胸部X线及不良反应。结果治疗组患儿咳嗽缓解时间、体温恢复时间及住院时间较对照组均明显缩短,差异有统计学意义(P<0.05)。治疗2周后复查胸部X线治疗组24例(占63.1%)炎症基本吸收,对照组9例(占23.7%)炎症基本吸收,两组比较差异有统计学意义(χ2=12.05,P<0.05)。两组患儿均未发生严重不良反应。结论甲泼尼龙辅助治疗难治性支原体肺炎能更快地缓解临床症状及促进炎症吸收,缩短住院时间,不良反应少,值得临床推广使用。Objective To explore the clinical effect of methylprednisolone in adjunctive therapy of refractory mycoplasma pneumonia（RMP）.Methods Seventy-six RMP children admitted to our department from the year of 2008 to 2010 were divided randomly into groups control（given antibiotics）and therapy（given additional small dosage of methylprednisolone）.Cough relief time,temperature recovery time,hospital stay,chest X-ray and adverse reactions were compared between 2 groups.Results Cough relief time,temperature recovery time and hospital stay were significantly shorter in therapy group than in control（P〈0.05）.By chest X-ray 2 weeks after treatment,inflammation was absorbed essentially in 24 of therapy group（63.1%）,and in 9 of control group（23.7%）,the difference was significant（χ^2=12.05,P〈0.05）.No severe adverse reactions occurred in 2 groups.Conclusion Methylprednisolone in adjunctive therapy of RMP,which can relieve clinical symptoms and promote inflammation absorption more rapidly with shorter hospital stay and fewer adverse reactions,is worthy of clinical use.

关 键 词：甲泼尼龙 肺炎 支原体 治疗结果 

分 类 号：R725.631.3[医药卫生—儿科]