干细胞移植在心肌梗死治疗中的应用进展  

Application of Stem Cell Transplantation in Myocardial Infarction

作　　者：胡依民[1] 

机构地区：[1]中国医学科学院中国协和医科大学血液学研究所,天津市300020

出　　处：《中国全科医学》2011年第2期221-223,共3页Chinese General Practice

摘　　要：心肌梗死的病理生理进程中均存在心肌细胞的死亡或凋亡,心肌细胞数量减少。心肌梗死后,存活的心肌细胞代偿性肥大,心室重塑,心功能下降,现行的治疗方法只能通过缩小心肌梗死的范围、恢复缺血的存活心肌的血液供应、延缓左室重构,以改善患者的预后,而不能从根本上修复坏死的心肌组织。最新的动物实验和临床研究表明,移植干细胞到心肌细胞坏死区域内,可有效补充心肌细胞,改善心功能。因此,干细胞移植可能是治疗心肌梗死、再生心肌、防止左室重构和预防心功能衰竭的最有希望的治疗方法,而且治疗手段简便、受益人群广、有着广阔的应用前景。In the pathophysiological process of myocardial infarction（MI）,myocardial cells are found dead or apoptosis with reduction in the number of myocardial cells.After MI occurs,the survival myocardial cells become compensatory hypertrophy and ventricles remodeled,which leads to decreased heart function.Current treatment can only narrow the extent of MI,recover blood supply in the survival ischemic myocardium and delay left ventricular remodeling to improve prognoses,rather than repair fundamentally the necrotic myocardial tissues.The latest animal experiments and clinical studies show that stem cell transplantation into the necrotic area of myocardial cells can effectively complement myocardial cells and contribute to cardiac function improvement.Stem cell transplantation,probably the most promising treatment for MI,myocardial regeneration,prevention of left ventricular remodeling and heart failure,is easy to perform,having wide beneficiaries and a broad application prospect.

关 键 词：干细胞移植 心肌梗死 心室重构 

分 类 号：R542.22[医药卫生—心血管疾病]