不同剂量沙美特罗替卡松在慢性阻塞性肺疾病稳定期中的疗效对比研究  

The Clinical Observation of Different Dosage Forms Salmeterol Fluticasone Propionate in the Patients with Stable Chronic Obstructive Pulmonary Disease

作　　者：杨勇刚[1] 胡强[1] 王利玲[1] 陈余思[1] 

机构地区：[1]攀枝花学院附属医院呼吸科,四川省攀枝花市617000

出　　处：《实用心脑肺血管病杂志》2011年第1期18-20,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨不同剂量沙美特罗替卡松在慢性阻塞性肺疾病稳定期中的疗效。方法选取2008年1月—2010年2月于我院进行治疗的117例慢性阻塞性肺疾病患者为研究对象,将患者随机分为A组(舒利迭50/250μg剂型组)39例和B组(舒利迭50/500μg剂型组)39例,C组(万托林联合茶碱缓释片组)39例,后将A、B及C组治疗总有效率及治疗3个月及1年时的血气、血流变、肺功能指标、血清ET-1、IL-1β、NO的水平及6min步行距离进行统计及比较。结果经研究比较发现,B组的治疗总有效率高于A组及C组,治疗后3个月及1年时B组的血气、血流变、肺功能指标及6min步行距离的评价结果均优于A组及C组,而B组血清ET-1、IL-1β、NO水平均低于A组及C组,均有显著性差异,且B组患者在1年的疗程中急性加重的次数要低于A组及C组。结论大剂量沙美特罗替卡松在慢性阻塞性肺疾病稳定期中的综合效果要优于小剂量,值得临床推广应用。Objective To study the etficacy of different dosage forms salmeterol fluticasone propionate in the patients with stable chronic obstructive pulmonary disease. Methods 117 patients with stable chronic obstructive pulmonary disease in our hospital from January 2008 to February 2010 were selected as research object, and they were randomly divided into group A （50/250μg group） 39 cases, group B （50/500μg group） 39 cases and group C （ventolin combined with theophylline sustained release tablets） 39 cases. Then the total effective rate of group A and group B, the blood gas, blood flow change, lung function index, six minutes walking distance, levels of serum ET - 1 , IL - 1β, NO of group C and group A and B after the treatment at 3 month and 1 year were analyzed and compared. Results The total effective rate of group B was higher than that of group A, and the blood gas, blood flow change, lung function index six minutes walking distance of group B were better than those of group A and group C, and the levels of serum ET - 1, IL - 1β, NO of group B were all lower than those of group A and group C, there were significant differences. Conclusion The effects of high dose salmeterol fluticasone propionate in the patients with stable chronic obstructive pulmonary disease is better than that of low dose, and is worthy of popularization and application.

关 键 词：不同剂量 沙美特罗替卡松 慢性阻塞性肺疾病稳定期 疗效 

分 类 号：R563.3[医药卫生—呼吸系统]