不同浓度的非那雄胺固体脂质纳米粒的制备  

The Fabrication of Different Concentrations of Solid Lipid Nanoparticles of Finasteride

作　　者：梁刘萍[1] 李莉[1] 种树彬[1] 周美凤[1] 

机构地区：[1]南方医科大学附属南方医院皮肤科,广东广州510515

出　　处：《河北医学》2011年第1期64-65,共2页Hebei Medicine

基　　金：广东省医学科学技术研究基金(WSTJJ2006120440111197201018820)

摘　　要：目的:摸索出非那雄胺固体脂质纳米粒的制备方法。方法:采用改良的乳化蒸发-低温固化法将非那雄胺包封于固体脂质纳米粒中,制备0.1%、0.5%、1%不同浓度非那雄胺-固体脂质纳米粒(finasteride Solid lipid nanoparticles,FSLN)混悬液,观察其外观,用透射电镜考察其形态。结果:仅有0.1%非那雄胺-固体脂质纳米粒外观均匀,粒径为(98.2±15.3),包封率96.3%。结论:0.1%非那雄胺-固体脂质纳米粒包封率高,粒径分布较均匀,具有一定的稳定性。Objective： To explore the fabricaton of different concentrations of solid lipid nanoparticles.Method： The fabrication of 0.1%,0.5% and 1% concentrations of solid lipid nanoparticles of finasteride encapsulated by improved emulsion evaporation-low temperature.Then observed the appearance of the morphology under transmision electron microscopy.Result： There＇s 0.1% solid lipid nanoparticles of finasteride appearance of homogenous,the particle size was（98.2±15.3）.The rate of encapsulation was 96.3%.Conclusion： There＇s high entrapment efficiency of 0.1% concentrations of solid lipid nanoparticles of finasteride with the appearance of homogneous and stability.

关 键 词：非那雄胺 固体脂质纳米粒 浓度 

分 类 号：R94[医药卫生—药剂学]