关节软骨运动损伤修复中的骨形态发生蛋白  

Bone morphogenetic protein in the repair of articular cartilage injury

作　　者：于国辉[1] 

机构地区：[1]通化师范学院体育系,吉林省通化市134002

出　　处：《中国组织工程研究与临床康复》2010年第46期8669-8672,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：通化师范学院科研基金项目(201074)~~

摘　　要：背景:骨形态发生蛋白是一种常用的组织工程支架材料,它在关节软骨损伤修复中起着不可替代的作用。目的:介绍关节软骨损伤修复的方法、骨形态发生蛋白的分类;重点阐述骨形态发生蛋白在运动性关节软骨损伤修复中的应用。方法:以"骨形态发生蛋白,运动损伤,关节软骨,修复"为中文检索词;以"bone morphogenetic protein,sports injuries,articular cartilage,repair"为英文检索词,应用计算机检索Pubmed数据库和维普数据库1998-01/2010-04的相关文章。纳入与骨形态发生蛋白关节软骨损伤修复研究相关的文献,排除重复性研究。结果与结论:共检索到74篇文献,排除无关重复的文献,保留20篇文献进行综述。目前研究证实骨形态发生蛋白具有强大的促成骨活性,能够诱导间充质细胞不可逆地分化为骨、软骨组织;但骨形态发生蛋白家族各成员诱导成骨作用的能力不同,其中骨形态发生蛋白2和骨形态发生蛋白7的成骨能力最强。同时相关研究表明骨形态发生蛋白对关节软骨损伤修复具有促进作用,但要将其应用于临床仍存在作用机制不明、复合材料的选择、应用于人体的安全性和有效性等问题。BACKGROUND：Bone morphogenetic protein is a common scaffold material in tissue engineering,which plays an irreplaceable role in the repairing of articular cartilage injury.OBJECTIVE：To introduce the repairing ways of articular cartilage injury and the classification of bone morphogenetic protein;emphasize the application of bone morphogenetic protein in the repairing of articular cartilage injury.METHODS：Using ＂bone morphogenetic protein,sports injuries,articular and cartilage,repairing＂ as keywords in both Chinese and English to retrieve Pubmed Database and VIP Database for relevant documents published from January 1998 to April 2010.Papers addressing bone morphogenetic protein in the repair of articular cartilage injury were selected,and the repetitive studies were excluded.RESULTS AND CONCLUSION：A total of 74 pieces of document have been searched and 20 of them were introduced in the literature review,with the others deleted.At present,it has been proved that bone morphogenetic protein contributes greatly to the activation of bone and leads mesenchymal cell to differentiate into bone and cartilage irreversibly.However,the members of bone morphogenetic protein family differ in capacity of leading the formation of bone and the most capable ones are bone morphogenetic protein-2 and bone morphogenetic protein-7.Meanwhile it is shown in some relevant study that,bone morphogenetic protein has auxo-action in the repairing of articular cartilage injury.There is still a long way to go to apply bone morphogenetic protein to clinical treatment because of the indefinite mechanism of action,the option of composite material,the indefinite security and effectiveness of applying bone morphogenetic protein to human bodies.

关 键 词：关节软骨 运动损伤 骨形态发生蛋白 修复 骨组织工程 

分 类 号：R318[医药卫生—生物医学工程]