羟基香茅醛缩醛类化合物的合成及对蚊虫的驱避活性  

Synthesis of acetal derivatives of hydroxycitronellal and their repellent activity against mosquitoes

作　　者：王宗德[1] 陈金珠[1] 宋湛谦 姜志宽[3] 韩招久[3] 宋杰 

机构地区：[1]江西农业大学林学院,南昌330045 [2]中国林业科学研究院林产化学工业研究所国家林业局林产化学工程重点开放实验室,南京210042 [3]南京军区疾病预防控制中心,南京210002 [4]Department of Chemistry and Biochemistry,University of Michigan-Flint

出　　处：《昆虫学报》2010年第11期1241-1247,共7页Acta Entomologica Sinica

基　　金：国家自然科学基金项目(30860223;31060101);江西省青年科学家(井冈之星)培养对象计划;江苏省自然科学基金项目(BK2009040)

摘　　要：为了寻找新的萜类驱避剂,以羟基香茅醛为原料,合成羟基香茅醛二甲缩醛、羟基香茅醛乙二醇缩醛、羟基香茅醛1,3-丙二醇缩醛和羟基香茅醛1,2-丙二醇缩醛,用红外光谱IR、质谱MS分析其结构,对羟基香茅醛1,2-丙二醇缩醛还进行了1HNMR及13CNMR分析。按国标GB/T13917.9-2009测定了它们对白纹伊蚊Aedesalbopictus、中华按蚊Anopheles sinensis及淡色库蚊Culexpipiens的驱避活性。结果表明:10%(质量分数)羟基香茅醛二甲缩醛和羟基香茅醛1,2-丙二醇缩醛对中华按蚊的驱避时间均达到国标B级;羟基香茅醛1,2-丙二醇缩醛还对其他的蚊虫具有驱避作用,20%(质量分数)羟基香茅醛1,2-丙二醇缩醛对白纹伊蚊的驱避时间超过国标B级;10%(质量分数)羟基香茅醛1,2-丙二醇缩醛对淡色库蚊的驱避时间超过国标A级。这些结果说明它们对不同蚊种驱避活性的差别,为不同场合的驱蚊需要提供了理论基础。In order to seek novel terpenoid repellent,4 acetal derivatives of hydroxycitronellal,i.e.,hydroxycitronellal dimethyl acetal,hydroxycitronellal 1,2-ethandiol acetal,hydroxycitronellal 1,3-propanediol acetal and hydroxycitronellal 1,2-propanediol acetal,were synthesized in this study.Their structures were characterized using IR and MS,1H NMR,and 13C NMR（for hydroxycitronellal 1,2-propanediol acetal only）.Repellencies against Aedes albopictus,Anopheles sinensis and Culex pipiens were examined using the method described in GB/T 13917.9-2009.The results showed that the repellent activity of 10%（mass） solution of both hydroxycitronellal dimethyl acetal and hydroxycitronellal 1,2-propanediol acetal against A.sinensis reached grade B as defined in GB/T 13917.9-2009,and that of a concentrated solution（20% in mass） of hydroxycitronellal 1,2-propanediol acetal against A.sinensis even approached to grade A.Hydroxycitronellal 1,2-propanediol acetal also showed the repellency to other mosquitoes as well：the repellent activity of 20%（mass） solutions against A.albopictus and that of 10%（mass） solutions against C.pipiens exceeded the grades B and A,respectively.These results indicate that the repellent activity difference against different mosquito species offers the theoretical basis for using the repellents in different situations.

关 键 词：羟基香茅醛 缩醛类化合物 白纹伊蚊 中华按蚊 淡色库蚊 驱避活性 

分 类 号：Q965[生物学—昆虫学]