中国EV71病毒VP1蛋白生物信息学分析  

Bioinformatics analysis of VP1 protein of EV71 from China

作　　者：李建强[1] 李薇[1] 张予超[1] 高晶晶[1] 赵祖波[1] 杨俊杰[1] 

机构地区：[1]兰州生物制品研究所,兰州730000

出　　处：《微生物学免疫学进展》2010年第4期1-5,共5页Progress In Microbiology and Immunology

基　　金：甘肃科技重大专项(092GKDA010)

摘　　要：以肠道病毒71型(Enterovirus71,EV71)VP1蛋白基因序列为基础,利用生物软件对EV71病毒中国分离株VP1蛋白进行进化树、N-糖基化位点、二级结构及抗原位点的预测和分析。结果显示国内分离株多为C4亚型,有3株湖南分离株为A型,提示疫苗的研发应着重于预防C4b亚型EV71疫苗的研发。Based on the sequence of VP1 protein of enterovirus71（EV71）,the N-glycosylation site,secondary structure,B cell epitope and the phylogeny tree were analyzed using bio-software.The results showed that all of the EV71 isolates from China belonged to EV71 type C4 except 3 strains which belong to EV71 type A from Hunan Province,the indicated is that the vaccine study should be focussed on the EV71 type C4b.

关 键 词：手足口病 EV71病毒 VP1蛋白 生物信息学分析 

分 类 号：R373.2[医药卫生—病原生物学]