优化散射系数在脱水剂脱水效果评价中的应用研究  

Assessment of Hyperosmotic Solution Anhydration by the Use of Reduced Scattering Coefficients Measured in Rat's Local Cortex

作　　者：戴丽娟[1] 花国然[1] 钱志余[2] 

机构地区：[1]南通大学机械工程学院,南通226019 [2]南京航空航天大学生物医学工程系,南京210016

出　　处：《生物医学工程学杂志》2010年第6期1202-1205,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30671997);江苏省自然科学基金资助项目(BK2008184);南通市自然科学基金资助项目(K2009044);南通大学自然科学基金资助项目(08Z019;09R06)

摘　　要：本文利用双光纤微创探头和近红外光谱技术研究大鼠脑组织优化散射系数(μs’)在高渗溶液脱水作用评估方面的可行性。将60只SD大鼠随机分成A、B、C三组,每组分别在尾静脉推注0.9%NaCl、20%甘露醇和7.5%NaCl(均为10 ml/kg)。通过双光纤微创近红外光谱技术实时在位测量推注前后大鼠局部脑皮质μs’的变化情况。结果表明:A组推注前后μs’未见明显变化;B组和C组推注后μs’相对变化率分别上升7.3%±1.7%和12.8%±2.9%,三组间的差别存在统计学意义。通过双光纤微创近红外光谱技术测量大鼠局部脑皮质μs’可作为一种评估高渗溶液脱水作用的新方法,具有实时在位可重复性好的优点,值得进行深入的探讨。A new method that uses the reduced scattering coefficients（μ＇s） measured in rat＇s brain tissue in vivo after administration of hyperosmotic solution by bifurcated fiber optic probe is proposed in this paper.60 SD rats were divided into three groups by randomization method,and then were treated by 0.9% NaCl,20% Mannitol and 7.5% NaCl through vena caudalis,respectively.The changes of μ＇s in every rat＇s local cortex were observed continuously by a bifurcated fiber optic probe in vivo in a mini-invasive way.No changes of μ＇s were observed in the control group which was given by 0.9% NaCl,while the μ＇s relative changes of the 20% mannitol group and 7.5% NaCl group increased by 7.3%±1.7% and 12.8%±2.9%,respectively.The results showed that there were significant differences among the three groups（P0.05）.The μ＇s of rat＇s local cortex observed by bifurcated fiber optic probe can be used for shedding light on the anhydration induced by hyperosmotic solution.

关 键 词：高渗溶液 优化散射系数 近红外光谱 

分 类 号：R318.51[医药卫生—生物医学工程]