初治鼻咽癌调强放疗与常规放疗的放疗副反应对照研究  

The Complications of Different Radiotherapy for Nasopharyngeal Carcinoma： IMRT Versus Conventional Radiotherapy

作　　者：刘伊辉[1] 孙瑞美[1] 杨兆禄[1] 张学成[1] 

机构地区：[1]潍坊医学院附属医院放疗科,山东潍坊261031

出　　处：《潍坊医学院学报》2010年第5期389-391,共3页Acta Academiae Medicinae Weifang

摘　　要：目的探讨调强适形放疗技术在减轻鼻咽癌患者放疗后副反应，提高生存质量的临床意义。方法回顾性分析84例行调强放疗的初诊鼻咽癌患者，按1：1配对选择同期行常规放疗的84例初诊鼻咽癌患者作对照组，比较两组患者放疗后副反应。结果调强放疗组患者的急性皮肤反应、颈部纤维化、张口困难、口干均明显轻于常规放疗组（P〈0．05）；两组的急性黏膜反应、骨髓抑制、听力损伤差异无统计学意义（P〉0．05）。结论调强放疗能减轻患者的放疗副反应，改善生活质量。Objective To explore whether three dimensional conformal radiotherapy（3D CRT） can relieve the radiotherapy complications and improve the life quality for patients with primary nasopharyngeal carcinoma（ NPC ）. Methods Eighty-four patients with primary nasopharyngeal carcinoma treated by 3D CRT were retrospectively reviewed. Eighty-four patients treated with conventional radiotherapy during the same period were matched respectively by prognostic factors. The radiotherapy complications between the two groups were compared. Results A significant relief of the occurrence rate and severity of acute skin reaction, neck fibrosis,trismus and xerostomia was noted in intensity modulation radiated therapy（IMRT） arm. But there were no differences in mucositis, hematological toxicity, hearing loss between IMRT arm and CRT arm. Conclusion IMRT technique reduced the radiation-related complications in patients with NPC. It should be widely applied.

关 键 词：鼻咽肿瘤 放射疗法 调强放疗 预后 放射损伤 

分 类 号：R815[医药卫生—放射医学] R739.6[医药卫生—临床医学]