疏血通注射液对大鼠佐剂性关节炎的治疗作用研究  

THERAPEUTIC EFFECT OF SHU XUE TONG INJECTION IN THE ADUVANT ARTHRITIS

作　　者：解海霞[1] 陈学旻[1] 张青[1] 

机构地区：[1]佳木斯大学附属第一医院风湿免疫科,黑龙江佳木斯154003

出　　处：《牡丹江医学院学报》2010年第6期16-18,共3页Journal of Mudanjiang Medical University

摘　　要：目的:探讨疏血通注射液对大鼠佐剂性关节炎的治疗作用及对细胞因子IL-1、TNF-aI、L-4的影响。方法:选取Wister雌性大鼠24只,随机分为三组:造模组﹑疏血通注射液治疗组﹑地塞米松注射液治疗组。每组8只。每组大鼠右足跖皮内注射完全弗氏佐剂0.1mL复制佐剂性关节炎模型。用酶联免疫法测定大鼠血TNF-a﹑IL-1﹑IL-4水平。结果:疏血通注射液能改善大鼠的一般情况,能使佐剂关节炎大鼠血清中TNF-a﹑IL-1显著降低I,L-4水平显著升高﹙P﹥0.01﹚。结论:疏血通注射液是通过活血化瘀﹑扩张血管﹑改善微循环从而下调致炎因子TNF-a﹑IL-1、上调抗炎因子IL-4、抑制致炎效应,增强抗炎效应,使得Th1/Th2达到平衡。从而降低关节炎指数、消除肿胀。Objective：The aim of this study is to observe the therapeutic effect of ShuXueTong injection and measure the cytokine IL-1,IL-4,TNF-a by ELISA in the adjuvant arthritis.Methods：Twenty-four female Wistar rats were randomly divided into three groups：the model group,the ShuXueTong group,the Dexamethasone injectiongroup,the three groups were intracutaneously injected with 0.1mL Freunds mto adjuvant in the right hind limb to renlicate adjuvant arthritis model.The levels of IL-1,IL-4,TNF-a were measured by ELISA.Results：ShuXueTong injection can improve adjuvant arthritis rats generally,reduce rats serum TNF-a、IL-1 level adjuvants arthritis with the,and improve the level of IL-4.Conclusion：ShuXueTong injection is through invigorate the dilation of blood vessels,improve microcirculation,reduce inflammation factors TNF-a,IL-1,raise the anti-inflammatory factor of IL-4,regulate inflammatory effects,enhance the anti-inflammatory effect and make Th1/Th2 balance.Arthritis index was reduced and swelling eliminate.

关 键 词：佐剂性关节炎 疏血通注射液 细胞因子 TNF-a﹑IL-1I、L-4 

分 类 号：R593[医药卫生—内科学]