自体骨髓干细胞联合辛伐他汀治疗脊髓损伤  

Combination therapy of autologous bone marrow stem cells and simvastatin for neurologic disfunction in patient with spinal cord injury

作　　者：姜金豆[1] 步星耀[1] 程培训[1] 李志营[1] 张圣旭[1] 

机构地区：[1]河南省人民医院神经外科,河南郑州450003

出　　处：《河南医学研究》2010年第4期434-437,共4页Henan Medical Research

基　　金：河南省科技攻关重点项目(0424410054)

摘　　要：目的:探讨辛伐他汀联合自体骨髓干细胞(BMSCs)动员与手术移植治疗脊髓损伤(SCI)的临床疗效。方法:对132例SCI患者分别采用BMSCs动员、移植联合辛伐他汀、单独辛伐他汀治疗以及常规治疗。测定各组外周血CD133+CD34+细胞数,并行Barthel指数和ASIA评分,神经电生理及对比分析。结果:治疗后动员及移植组患者ASIA评分和Barthel指数以及外周血CD133+CD34+细胞数分别显著高于其它2组(P<0.05)。未出现1例明显毒副反应。结论:自体BMSCs联合辛伐他汀治疗SCI,可以促进神经功能的恢复,提高患者生活能力和质量,是治疗SCI安全有效方法。自体BMSCs动员较手术移植更简便、无创,实用性强,值得临床推广。Objective： To assess the safety and efficacy of combination therapy of autologous bone marrow stem cells（BMSCs） and simvastatin after spinal cord injury.Methods： 132 patients with complete SCI were enrolled and treated with combination therapy of BMSCs transplantation,mobilization and simvastatin,simvastatin monotherapy and routine medical therapy.The patients underwent preoperative and follow-up neurological assessment using the American Spinal Injury Association Impairment Scale（AISA）,Barthel index and electrophysiological monitoring. Peripheral blood CD133＋CD34＋ cells were analyzed with flow cytometer.Results： Significant functional improvement was seen（the AISA,Barthel index,CD133＋CD34＋ cells and electrophysiology scale assessment） in patients receiving combination therapy.No patients experienced serious complications during the treatment.Conclusion： Combination therapy of autologous bone marrow stem cells and simvastatin could enhances functional recovery after spinal cord injury.The treatment of BMSCs mobilization combined with simvastatin are more convenient,non-invasive and practicable compared with the therapy of BMSCs transplantation.

关 键 词：骨髓干细胞 移植 动员 辛伐他汀 SCI 

分 类 号：R651.2[医药卫生—外科学]