婴幼儿闭塞性细支气管炎的肺功能改变  

Pulmonary function changes of infants with bronchiolitis obliterans

作　　者：饶小春[1] 焦安夏[1] 马渝燕[1] 潘跃娜[1] 张琪[1] 江沁波[1] 

机构地区：[1]首都医科大学附属北京儿童医院北京市儿科研究所支气管镜中心,北京100045

出　　处：《山西医科大学学报》2010年第12期1080-1081,共2页Journal of Shanxi Medical University

摘　　要：目的观察婴幼儿闭塞性细支气管炎的肺功能变化情况。方法应用婴幼儿体描仪,对46例患闭塞性细支气管炎婴幼儿于吸入沙丁胺醇前后进行肺功能检测。结果 46例患儿吸入沙丁胺醇前潮气呼吸流速-容量环呼气降支凹陷;达峰容积比(VPEF/VE)、达峰时间比(tPTEF/tE)、吸呼气时间比(ti/te)和每千克体重呼吸系统顺应性(Crs/kg)降低;呼吸系统阻力(Rrs)和每千克体重功能残气量(FRC/kg)增加;而中期流速比(TEF50/TIF50)有18例降低,28例正常。46例患儿吸入沙丁胺醇后达峰容积比、达峰时间比等肺功能指标均无明显改善。结论婴幼儿闭塞性细支气管炎肺功能是以小气道为主的阻塞性通气功能障碍,舒张试验阴性。肺功能测定能很好地反映本病病情。Objective To observe the alteration of pulmonary function in infants with bronchiolitis obliterans. Methods The pulmonary function was determined in 46 infants with bronchiolitis obliterans before and after salbutamol inhalation. Results Before salbutamol inhalation,the tidal breathing flow-volume loop displayed a concave expiratory curve.The expiratory volume till peak flow divided by the total expiratory volume（VPEF/VE） ,ratio of time to reach tidal peak flow to total expiratory time（tPTEF/tE） ,ratio of inspiratory time and expiratory time,respiratory system compliance per kilogram significantly decreased,while respiratory system resistance and functional residual capacity per kilogram were significantly increased.The ratio of mid-expiratory to mid-inspiratory flow significantly decreased in 18 infants and normal in 28 infants.There was no significant difference in VPEF/VE and tPTEF/tE before and after salbutamol inhalation. Conclusion The pulmonary function present the obstructive ventilatory disturbance,mainly small airway obstruction in infants with bronchiolitis obliterans,with bronchodilation test negative.Pulmonary function detection can reflect the clinical characteristics.

关 键 词：闭塞性细支气管炎 肺功能 婴幼儿 

分 类 号：R562.21[医药卫生—呼吸系统]