Neural function rebuilding on different bodies using microelectronic neural bridge technique  

采用微电子神经桥实现的异体神经功能重建(英文)

作　　者：沈晓燕[1,2] 王志功[1] 吕晓迎[3] 李文渊[1] 赵鑫泰[1] 黄宗浩[1] 

机构地区：[1]东南大学射频与光电集成电路研究所,南京210096 [2]南通大学电子信息学院,南通226019 [3]东南大学生物电子学国家重点实验室,南京210096

出　　处：《Journal of Southeast University(English Edition)》2010年第4期523-527,共5页东南大学学报（英文版）

基　　金：The National Natural Science Foundation of China(No.90307013,90707005);the Natural Science Foundation of Jiangsu Province(No.BK2008032);Special Foundation and Open Foundation of State Key Laboratory of Bioelectronics of Southeast University;Nantong Planning Project of Science and Technology(No.K2009037)

摘　　要：A microelectronic circuit is used to regenerate the neural signals between the proximal end and the distal end of an injured nerve.An experimental scheme is designed and carried out to verify the feasibility of the so-called microelectronic neural bridge（MNB）.The sciatic signals of the source spinal toad which are evoked by chemical stimuli are used as source signals to stimulate the sciatic of the controlled spinal toad.The sciatic nerve signals of the source spinal toad,the regenerated sciatic signals in the controlled spinal toad,and the resulting electromyography（EMG）signals associated with the gastrocnemius muscle movements of the controlled spinal toad are displayed and recorded by an oscilloscope.By analyzing the coherence between the source sciatic nerve signals and the regenerated sciatic nerve signals and the coherence between the regenerated nerve signals and the EMG signals,it is proved that the regenerated sciatic nerve signals have a relationship with the source sciatic nerve signals and control shrinkage of the leg of the controlled toad.介绍了在损伤的远端神经与近端神经间利用微电子神经桥实现神经信道桥接的技术,设计并实施了一个实验方案,验证了微电子模块实现神经信道桥接的可行性.以信源脊蟾蜍在化学刺激下诱发的坐骨神经信号作为信号源,激励受控脊蟾蜍的坐骨神经,控制其动作.通过示波器观察并记录了信源脊蟾蜍坐骨神经信号、再生后的受控脊蟾蜍坐骨神经信号及其肌电信号.通过分析信源脊蟾蜍坐骨神经信号与受控脊蟾蜍坐骨神经信号以及受控脊蟾蜍坐骨神经信号与肌电信号间的互相干函数,证明再生后的受控脊蟾蜍坐骨神经信号与信源脊蟾蜍坐骨神经信号有关,并对受控脊蟾蜍的缩腿动作起着控制作用.

关 键 词：neural function regeneration electromy-ography（EMG） microelectronic neural bridge coherence function 

分 类 号：Q426[生物学—神经生物学]