比较研究奇正青鹏软膏与辣椒碱软膏的抗炎镇痛作用及机制  

Comparing study on anti-inflammatory and analgesic effect and mechanism of Qizheng Qingpeng Paste and capsaicin cream

作　　者：许文频[1] 王欣[2] 李敏[1] 李卫东[1] 

机构地区：[1]北京大学医学部基础医学院,北京100191 [2]山东中医药大学

出　　处：《中国临床药理学与治疗学》2010年第10期1100-1105,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:探讨奇正青鹏软膏(简称青鹏软膏)和辣椒碱软膏在治疗关节炎疼痛作用及机制上存在的相似性及差异性。方法:分别用两种药物预处理大鼠,观察两药作用下福尔马林致痛模型大鼠的疼痛行为反应、局部组织病理变化、足底炎性痛局部组织P物质(SP)的表达、血清一氧化氮(NO)的水平以及血浆β-内啡肽(β-EP)的水平。结果:与模型组比较,青鹏软膏及辣椒碱各剂量组均能明显改善局部组织病理状况,并显著降低大鼠SP阳性细胞积分光度值(P<0.01);青鹏软膏两剂量组和辣椒碱大剂量组均抑制福尔马林II相疼痛、降低血清NO水平(P<0.05),并提高血浆β-EP的水平(P<0.05)。与辣椒碱相比,青鹏软膏没有局部刺激作用,其作用具有剂量依赖性,并且对福尔马林Ⅰ相疼痛有抑制作用。结论:青鹏软膏与辣椒碱的镇痛作用机制有很大的相似性,但青鹏软膏的作用可能更加广泛和可控。AIM：To investigate the similarity and difference of effects and mechanisms between Qingpeng Paste and capsaicin cream on arthritis.METHODS：The rats of formalin inflammatory pain model were pretreated with the two drugs,pathologic changes and substance P expression of the tissues,serum NO level and the plasma level of β endorphin were measured,and the behavior change was observed.RESULTS：Compared with model group,each dosage of Qingpeng Paste and capsaicin cream could greatly improve the pathologic changes and decrease the level of substance P.Two dosages of Qingpeng Paste and high dosage of capsaicin cream could inhibit the second phase of formalin inflammatory pain,decrease the level of serum NO,and increase the level of plasma β endorphin.Compared with capsaicin cream,Qingpeng Paste could restrain the fist phase of formalin inflammatory pain,had no simulative effect of high dosage capsaicin cream and had an analgesic effect in a dose-dependant manner.CONCLUSION：There is much comparability between effects and mechanism of Qingpeng Paste and capsaicin cream on arthritis.However,comparing with capsaicin,Qingpeng Paste might has wider and more controllable pharmacological functions.

关 键 词：青鹏软膏 辣椒碱 关节炎 福尔马林疼痛 

分 类 号：R965.2[医药卫生—药理学]