β-榄香烯对早期实验性变态反应性脑脊髓炎小鼠视神经炎的治疗作用  

Therapeutic effect of β-elemene on early optic neuritis in experimental allergic encephalomyelitis mice

作　　者：张荣伟[1] 陈蕾[2] 

机构地区：[1]中国医科大学附属第一医院老年病干诊科 [2]中国医科大学附属第一医院眼科

出　　处：《中国临床药理学与治疗学》2010年第10期1128-1132,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：辽宁省教育厅资助项目(2009A733)

摘　　要：目的:探讨β-榄香烯对实验性变态反应性脑脊髓炎(experimental allergic encephalomyeli-tis,EAE)小鼠早期视神经炎的神经保护作用。方法:通过形态学观察EAE模型组及β-榄香烯干预组小鼠视神经的病理学改变;免疫组化方法检测二组视神经β淀粉样前体蛋白(β-amyloid precursor protein β,β-APP)、2,3-环核苷3磷酸二酯酶(2,3-cyclic nucleopide 3-phosphdiesterase,CNPase)蛋白表达。结果:β-榄香烯干预组小鼠视神经的炎症反应较模型组明显减轻,正常髓鞘蛋白CNPase的表达较模型组增加(31.8±1.0vs10.6±0.7,P<0.05),轴索损害的标志物β-APP蛋白的表达较模型组减少(80.4±9.4vs182.7±9.1,P<0.05)。结论:β-榄香烯可保护EAE小鼠视神经的髓鞘及轴索损害。AIM：To investigate the therapeutic effect of β-elemene on early optic neuritis in experimental allergic encephalomyelitis（EAE）mice.METHODS：The morphological changes of optic nerve in EAE group and β-elemene treated group were observed by morphology;the expression of β-amyloid precursor protein（β-APP）and 2,3-cyclic nucleopide 3-phosphdiesterase（CNPase） proteins were detected by immunohistochemistry.RESULTS：Compared with the EAE model group,the inflammation of optic nerve in β-elemene treated group was reduced,the expressions of CNPase were increased（31.8±1.0 vs 10.6±0.7,P0.05）and the expressions of β-APP were decreased（80.4±9.4 vs 182.7±9.1,P0.05）in β-elemene treated group.CONCLUSION：β-elemene can protect the optic nerve myelin and axon from the damage in EAE mice.

关 键 词：Β-榄香烯 实验性变态反应性脑脊髓炎 Β淀粉样前体蛋白 2 3-环核苷3磷酸二酯酶 

分 类 号：R965.2[医药卫生—药理学]