瑞舒伐他汀对慢性心力衰竭患者血清中细胞因子浓度的影响  

Effects of rosuvastatin on serum soluble cell adhesion molecule levels in patients with chronic heart failure

作　　者：胡立群[1] 章琦[1] 陈莉[1] 李红旗[1] 尹长森[1] 

机构地区：[1]安徽医科大学附属安徽省立医院安徽省心血管病研究所

出　　处：《中国临床药理学与治疗学》2010年第10期1152-1155,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：安徽省卫生厅临床医学研究项目(2008B023)

摘　　要：目的:观察瑞舒伐他汀短期治疗对慢性心力衰竭(chronic heart failure,CHF)患者血清中可溶性选择素-E(sE-selectin)和P(sP-selectin)水平的影响。方法:70例CHF患者随机分为常规治疗组和干预组,常规治疗组给予强心、利尿、扩血管治疗,干预组在此基础上加用瑞舒伐他汀10mg/晚,治疗4周。采用ELISA测定其治疗前后血清中sE-selectin和sP-selectin水平。结果:心功能Ⅳ级患者血清sE-selectin和sP-selec-tin明显高于心功能Ⅱ、Ⅲ级患者(P<0.01),而心功能Ⅱ、Ⅲ级组间比较差异无统计学意义(P>0.05)。两组治疗后血清sE-selectin和sP-selec-tin水平均较治疗前有显著下降(P<0.05或P<0.01),干预组sE-selectin下降水平优于常规治疗组(P<0.05),而sP-selectin水平组间比较差异无统计学意义(P>0.05)。结论:随着心功能恶化sE-selectin和sP-selectin水平明显升高,瑞舒伐他汀短期治疗能降低血清sE-selectin水平。AIM：To observe the effects of short-term treatment of rosuvastatin on soluble E-selectin（sE-selectin） and P-selectin（sP-selectin） in patients with congestive heart failure（CHF）.METHODS：70 patients with CHF were randomly divided into conventional treatment group and intervention group,the conventional treatment group received placebo and the intervention group received rosuvastain 10 mg /n for 4 weeks.The levels of sE-selectin and sP-selectin were measured before and after treatment by ELISA.RESULTS：The levels of sE-selectin and sP-selectin in serum of patients with heart function class Ⅳ were significantly higher than those in patients with heart function classⅡand Ⅲ（P0.01）,but there was no significant difference between classⅡand Ⅲ（P0.05）.The levels of sE-selectin and sP-selectin in two groups were significantly decreased after treatment（P0.05 or P0.01）,compared with the conventional treatment group,only the sE-selectin level was significantly decreased（P0.05）.CONCLUSION：The levels of sE-selectin and sP-selectin are significantly increased along with heart function deterioration.The level of sE-selectin is decreased with short-term rosuvastatin treatment.

关 键 词：慢性性心力衰竭 瑞舒伐他汀 sE-selec-tin和sP-selectin 

分 类 号：R965.2[医药卫生—药理学]