十六烷基三甲基溴化铵催化合成苯氧乙酸  

Catalytic Synthesis of Phenoxyacetic Acid with Cetyltrimethylammonium Bromide

作　　者：农邦写[1] 黄锁义[2] 程金生[2] 黄上峰[1,2] 

机构地区：[1]右江民族医学院临床医学系,广西百色53300 [2]右江民族医学院药学系,广西百色533000

出　　处：《化工技术与开发》2010年第12期5-7,共3页Technology & Development of Chemical Industry

基　　金：广西自然科学基金课题(桂科自0899022);广西教育厅课题(200710LX149)

摘　　要：利用十六烷基三甲基溴化铵催化氯乙酸和苯酚合成苯氧乙酸,十六烷基三甲基溴化铵具有较高的催化活性,可以加快合成苯氧乙酸。反应过程考察了苯酚与氯乙酸摩尔比、催化剂用量、反应时间、反应温度对产率的影响以及催化剂的重复使用性能。反应的最佳条件为:在80℃下,苯酚和氯乙酸的摩尔比为1∶3,催化剂质量为1.5g,反应时间为1.5h。此反应所得到的苯氧乙酸的产率为52.74%。该催化剂的用量很少,而且易于回收,并且可以重复使用。Phenoxyacetic acid was synthesized with chloroacetate and phenol,and cetyltrimethylammonium bromide was used as catalyst.Cetyltrimethylammonium bromide had a higher catalytic activity and could be accelerate the synthesis of phenoxyacetic acid.Molar ratio of phenol to chloroacetic acid,catalyst amount,reaction time and reaction temperature on yield and the performance of the repeated use of catalyst were studied.The best reaction conditions were as followed：at 80℃,molar ratio of phenol to chloroacetate 1：3,catalyst weight of 1.5g,reaction time 1.5h.The yield was 52.74%.

关 键 词：苯氧乙酸 氯乙酸 苯酚 十六烷基三甲基溴化铵 合成 

分 类 号：O625.5[理学—有机化学]