补体C3基因多态性与相关疾病研究进展  

Research Progress of Complement Component 3(C3) Gene Polymorphism with Related Diseases

作　　者：翟瑞燕[1,2] 王长法[1,2] 仲跻峰[2] 安利国[1] 

机构地区：[1]山东师范大学生命科学学院,山东济南250014 [2]山东省农业科学院奶牛研究中心,山东济南250100

出　　处：《家畜生态学报》2010年第6期92-96,共5页Journal of Domestic Animal Ecology

基　　金：国家高技术研究发展计划(863)(2007AA10Z169;2006AA10Z1D9);全国奶牛现代农产品加工技术研发体系(nycytx-0107;nyhyzx07-036-09);山东省良种工程项目(2007LZ10-06);山东省重点科技攻关项目(2009GG20002033)

摘　　要：在补体各成分中,补体第三组分(C3)在血清中含量最高,是补体系统的核心。C3在功能上不仅处于补体经典途径、甘露糖结合凝集素途径和补体旁路途径三条激活途径的汇合点,还是C3b依赖的阳性反馈环路的基础;而且C3裂解片段及其结合蛋白复杂多样,在免疫防御、免疫调控以及免疫病理中发挥着重要的作用。当C3基因发生突变或缺失时会造成C3缺陷性疾病,常伴发免疫性疾病及反复细菌感染,患者对病原菌感染的易感性显著增加。论文概述了C3基因结构及其多态性以及其与机体易感性的关联性。The complement component 3（C3） which has the highest concentrations in the serum is the core of the complement system.As a very important innate immune molecular,the complement component C3 is not only the key molecule of the three pathways of complement activation（alternative,classical and lectin pathways）,but also is the basis of the positive feedback loop dependent in C3b.Its cleavage fragments and recepters are complex and diverse,which are involved in immune defense,immune regulation and immunopathology.The mutation or deletion of C3 gene can cause C3 deficient diseases,accompanied with immune diseases and recurrent bacterial infection,susceptibility of the patients increased significantly.This article summarized the structure of C3 gene and the relevance of organism susceptibility.

关 键 词：C3 多态性 免疫缺陷性疾病 易感性 

分 类 号：S811.5[农业科学—畜牧学]