益欣康泰胶囊对高原健康人体内氧自由基代谢作用的研究  

EFFECT OF YIXINKANGTAI ON FREE RADICALS IN THE HEALTHY SUBJECTS AT HIGH ALTITUDE

作　　者：阿祥仁 张鑫生 吕雪梅 郗爱旗 齐文斌 阮宗海[1,2] 

机构地区：[1]青海省老年医学研究所,810007 [2]青海省高原医学科学研究所,810001

出　　处：《高原医学杂志》1999年第2期52-54,共3页Journal of High Altitude Medicine

摘　　要：目的：观察益欣康泰对高原健康人体内自由基代谢指标超氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ—Ｐｘ）和丙二醛（ＭＤＡ）的影响。方法：选择３０５ 例生活在海拔３ ３００ｍ 地区的健康人进行服用益欣康泰前后体内ＳＯＤ、ＧＳＨ—Ｐｘ 活性和血清ＭＤＡ 含量的测定。结果：服药后健康人体内的ＳＯＤ和ＧＳＨ—Ｐｘ 活力显著升高（Ｐ＜００１），同时血清ＭＤＡ含量明显下降（Ｐ＜ ００１）。结论：提示该药具有调节和改善机体氧自由基代谢的水平，故对由之失衡而引起的高原人早老。To observe the effect of Yixinkangtai on the marks of metabolism of free radicals in healthy subjects at high altitude,including Superoxide dismutase(SOD),glutathion peroxide(GSH-Px)and malondialdehyde(MDA).Methods:SOD,GSH-Px and MDA were measured in 305 healthy subjects living at high altitude(3 300m)before and after taking Yixinkangtai.Results:The value of SOD and GSH-Px were increased significantly( P <0 01),and that of MDA was decreased markedly( P <0 01) in healthy subjects after administration of Yixinkangtai.Conclusions:It indicated that the drug can improve the metabolism of free radicals in healthy subjects at high altitude.So we predict that the drug can prevent early free radicals-induced aging at high altitude.

关 键 词：益欣康泰胶囊 自由基 高原 

分 类 号：R285.5[医药卫生—中药学] R188[医药卫生—中医学]