血液透析患者应用高通量透析的临床疗效观察  

Observation on clinical therapeutic effect of high-flux dialysis in the treatment of hemodialysis patients

作　　者：王洪玲[1] 田洁[1] 李春红[1] 徐婧[1] 魏肃[1] 

机构地区：[1]天津市第三中心医院肾内科天津市人工细胞重点实验室,300170

出　　处：《国际移植与血液净化杂志》2010年第6期27-30,共4页International Journal of Transplantation and Hemopurification

摘　　要：目的比较高通量透析与低通量透析对透析患者的治疗效果。方法40例维持性血液透析患者采用自身对照的方法，间断接受高通量透析及低通量透析治疗，总计48周。观察治疗过程中临床症状的改善情况，比较2种透析方式单次透析的效果，以及治疗过程中陡微球蛋白、C反应蛋白、白细胞、血清总补体水平的变化趋势。结果高通量透析期间临床症状缓解明显，且对岛微球蛋白的清除能力明显优于低通量透析，而对于小分子物质的清除能力比较差异无统计学意义（P〉0．05）。治疗过程中患者的C反应蛋白有下降趋势，但无统计学意义（P〉0．05），白细胞、血清总补体水平无明显变化。结论高通量透析能有效地清除隧微球蛋白，从而改善维持性血液透析患者的临床症状及预后。Objective To observe the effect between high-flux dialysis and low-flux dialysis in hemodialysis patients. Methods Forty maintenance hemodialysis patients adopted high-flux dialysis and low-flux dialysis alternatively for 48 weeks by self-control. The symptoms of patients and single-pass effect of each type were observed in the course of therapy. At the same time, β2-microglobulin, C-reactive protein, leucocyte and total complement in blood serum were detected. Results The high-flux dialysis was much better than low-flux dialysis at improving clinical symptoms and the clearance of β2-microglobulin. However, there was no statistical significance in the clearance of micromoleeular substances between two kinds of dialy- sises（ P 〉 0.05）. The level of C-reactive protein had a declining trend, however, without statistical significance（ P 〈 0.05 ）. Leucocyte and total complement in blood serum didn＇t change obviously. Conclusion The high-flux dialysis can clear β2-micmglobulin efficaciously. So it contributes to improve the clinical symptoms and prognosis of maintenance hemodialysis patients.

关 键 词：血液透析 高通量透析 Β2微球蛋白 

分 类 号：R692.5[医药卫生—泌尿科学]