雅施达与普罗布考联合应用对高血压患者动态的动脉硬化指数及血致动脉硬化指数的逆转作用  

Reversal Effection of Ambulatory Arterial Stiffness Index (AASI) and Atherogenic Index of Plasma(AIP)in Patients with Hypertension Applying Acertil and Probucol

作　　者：赵立卓[1] 郑万斌[1] 孙佳滨[1] 那世敬[1] 郭吉伟[1] 邓丽华[1] 

机构地区：[1]哈尔滨市第一医院心内科,黑龙江哈尔滨150010

出　　处：《中国伤残医学》2010年第6期24-25,共2页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨雅施达与普罗布考联合应用对高血压患者动态的动脉硬化指数及血致动脉硬化指数的影响。方法:87例患者每天清晨8时顿服培多普利4mg,治疗1周后,如舒张压仍》90mmHg者,计量增加到8mg/d,顿服,疗程8周。同时服用降血脂药普罗布考片0.5g,1天2次。治疗前后各查24小时动态血压监测及血脂五项。进行统计学处理及相关分析。结果:应用8周后,AASI、AIP明显下降,2者具有显著正相关性,有效延缓和控制了高血压和动脉硬化等心血管疾病的发展进程,降低了心血管危险因素及靶器官损伤。亦提示AASI、AIP是高血压及动脉硬化的临床防治以及为临床对高血压的风险因素早期采取措施进行干预疗效观察有效地而敏感的指标。Objective：To evaluate the affection on the Ambulatory Arterial Stiffness Index（AASI）and atherogenic index of plasma（AIP）in patients with hypertension applying acertil and probucol.Methods：87 patients were treated with perindopril 4mg early in the morning at 8：00.a week after treatment,If it did not reach target blood pressure（90 mm Hg）,then treated with perindopril 8mg /d for 8 weeks,At the same time taking Probucol 0.5g,twice a day.Before and after treatment ambulatory 24h blood pressure monitoring and blood lipids were evaluated for statistical analysis and correlation analysis.Results：After 8 weeks,AASI and AIP significantly decreased,and had significantly positive correlation.Treatment delayed and controlled the development process of cardiovascular diseases such as hypertension and atherosclerosis,and reduced cardiovascular risk factors and target organ damage.Conclusion：This suggested that AASI and AIP were effectively and sensitive indicators for the prevention and treatment of hypertension and arteriosclerosis as well as clinical risk factors of hypertension in early intervention.

关 键 词：动态动脉硬化指数 血浆致动脉硬化指数 原发性高血压 雅施达 普罗布考 

分 类 号：R97[医药卫生—药品]