新生儿败血症患者血清IL-6、TNF-α水平的变化及其意义  

THE CLINICAL SIGNIFICANCE OF SERUM INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR ALPHA ALTERATION IN NEONATES WITH SEPTICEMIA

作　　者：杨基龙[1] 刘克明[2] 林穗珍[2] 孙良忠[2] 

机构地区：[1]广东省禺市何贤纪念医院,511400 [2]中山医科大学附属第一医院儿科,510000

出　　处：《新生儿科杂志》1999年第5期193-195,共3页The Journal of Neonatology

摘　　要：为寻求有助于早期诊断新生儿败血症的方法 ,我们采用 EL ISA方法检测了 2 7例败血症新生儿血清 IL- 6、TNF- α水平 ,并与 30例对照组新生儿进行比较。结果表明 :败血症患儿血清 IL - 6、TNF-α水平均显著高于对照组新生儿。同时还发现败血症患儿 IL- 6的敏感性显著高于 TNF- α。另外 ,IL- 6与 CRP与联合诊断新生儿败血症的敏感性达 1 0 0 %。提示细菌感染时患儿血中 IL- 6、TNF-α升高 ,在新生儿败血症病程初期同时检测 IL - 6和The First Affiliated Hospital. Sun Yat University of Medical Sciences The serum levels of interleukin 6(IL 6) TNF α of 27 septicemia neonates were examined with ELISA method, and compared with that of 30 control neonates. The results indicated that ①Both IL 6 and TNF α of the septicemia neonates were significantly higher than that of the control newborns;②In neonatal septicemia group, sensitivity of IL 6 significantly higher than that of TNF α;③Combined of IL 6 and CRP can improve the sensitivity of early diagnosis to 100% We conclude that serum levels of IL 6 and TNF α are elevated in neonates with bacterial infection, and to measure serum levels of IL 6 and CRP at the same time in suspected septicemia neonates at early stage would be helpful for an early diagnosis of neonatal septicemia.

关 键 词：新生儿败血症 白细胞介素-6 肿瘤坏死因子 

分 类 号：R722.131[医药卫生—儿科]