高血压病患者胰岛素、糖和脂肪代谢的研究  

Abnormalities of Metabolism of Insulin,Glucose and Lipids in Hypertensive Patients

作　　者：李静[1] 王家良[1] 俞红吉[1] 吴泰相[1] 陈学芳 童式国[3] 

机构地区：[1]华西医科大学第一临床医学院临床流行病学教研室,成都610041 [2]成都无缝钢管总厂职工医院 [3]四川大学分析测试中心

出　　处：《中国慢性病预防与控制》1999年第5期205-207,共3页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：采用断面设计，随机选择高血压病患者１０２ 例，按高血压病家族史、性别、年龄配对选择１０２ 例正常血压者作为对照，比较胰岛素、糖、脂肪及细胞内外离子在两组的分布特点。结果显示：①高血压病组胰岛素、血糖、低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）、胆固醇（Ｃｈ）水平高于正常血压组，高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）低于正常血压组，但无显著性差异；高血压病组的甘油三酯（ＴＧ）及血清和淋巴细胞内Ｎａ＋ 、Ｃａ浓度均高于正常血压组，血清钾则低于正常血压组，且有统计学意义；②简单相关分析发现：胰岛素水平与ＬＤＬ－Ｃ、Ｃｈ、ＴＧ呈正相关，与ＨＤＬ－Ｃ呈负相关；血糖水平与Ｃｈ、ＴＧ呈正相关，收缩压和舒张压（ＤＢＰ）与ＢＭＩ和ＴＧ呈正相关；ＢＭＩ与ＴＧ呈正相关，均有统计学差异；③多元逐步回归分析表明ＤＢＰ和平均压与胰岛素及血清Ｎａ＋ 、Ｋ＋ 、Ｃａ和淋巴细胞内Ｃａ呈正相关。结论：提示高血压病患者有胰岛素水平增高和胰岛素抵抗的趋势，胰岛素、糖和脂肪代谢间存在密切相关关系。Objective:To study the levels of insulin,glucose,lipids and their effects in hypertensive patients(HBP).Method:A cross sectional study was carried out in 102 hypertensive cases.For every case,one control(NBP),individually macthed by sex,age and family history of hypertension,was randomly selected from the same community.The levels of serum and intralymphocytic sodium(Na),potassium(K),calcium(Ca),insulin,glucose,high and low density lipoprotein(HDL,LDL),cholesterol(Ch),trigly ceride(TG) as well as blood pressure,weight,height and family history of hypertension were measured.Results:①The levels of TG,serum and intralymphocytic Na,Ca were significantly higher,and the level of serum K was significantly lower in HBP than that in NBP( P <0 05);the levels of insulin,LDL,Ch,glucose were higher and the level of HDL was lower in HBP than that in NBP,but had no significant difference.②Simple correlation analysis showed that SBP,DBP were positively correlated with TG( r =0 19);glucose was positively correlated with Ch( r =0 25),TG( r =0 19);insulin was negatively correlated with HDL( r =-0 31),positively correlated with LDL( r =0 27),Ch( r =0 19),TG( r =0 21).③Multiple regression anlysis revealed that SBP was positively correlated with age,serum Ca and Ch,negatively correlated with serum K;DBP was positively correlated with insulin,age,serum and intralymphocytic Ca,but negatively correlated with serum K.Conclusion:This research revealed the existence of abnormal levels of insulin,lipids and glucose in HBP,which might provide useful information for further sdudy of the pathogenesis,complications and treatment of HBP.

关 键 词：高血压 胰岛素 血糖 胆固醇 

分 类 号：R544.1[医药卫生—心血管疾病]