软坚散结法对动脉粥样硬化影响的临床研究  

Clinical Study of Hardness-Softening and Mass-Dissipating Therapy in Treating Atherosclerosis

作　　者：李强 叶小汉 董明国 王婷 

机构地区：[1]东莞市中医院,广东东莞523005

出　　处：《新中医》2011年第2期66-68,共3页New Chinese Medicine

摘　　要：目的:观察软坚散结法对动脉粥样硬化斑块的防治作用。方法:将132例动脉粥样硬化的病人,随机分成对照组65例和治疗组67例,治疗组采用心脉康方每天1剂口服;对照组采用血脂康胶囊治疗。2组均给药3月。结果:2组总有效率比较,差异无显著性意义(P>0.05)。治疗组治疗后血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和对照组治疗后TG、TC、LDL-C分别与治疗前比较,差异均有显著性意义(P<0.05)。2组治疗后TG、LDL-C、HDL-C比较,差异均有显著性意义(P<0.05)。2组治疗前后动脉内膜-中膜厚度(IMT)、斑块消退比较,差异有显著性或非常显著性意义(P<0.05,P<0.01)。2组治疗后斑块消退比较,差异有显著性意义(P<0.05)。2组治疗期间心脑血管事件发生和再住院情况比较,差异均有非常显著性意义(P<0.01)。结论:软坚散结法能降低血脂,改善动脉粥样硬化。Objective： To evaluate the preventive and therapeutic effect of therapy of softening hardness and dissipating mass for atherosclerosis. Methods： One hundred and thirty-two atherosclerosis patients were randomly divided into two groups. The control group （n=65） received Xuezhikang Tablet, and the treatment group （n=67） received the decoction of Xinmaikang Prescription, one dose per day. The treatment lasted 3 months. Results： No statistical significant difference of the total effective rate was found between two groups （P 〉 0.05）. After treatment, serum levels of total cholesterol（TC）, triglyceride （TG）, low density lipoprotein cholesterol （LDL-C）, and high density lipoprotein cholesterol （HDL-C）in the treatment group differed from those before treatment（P 〈 0.05）. So did TG, TC, LDL-C in the control group（P 〈 0.05）. The differences of TG, LDL-C, HDL-C were significant between two groups after treatment （P 〈 0.05）. Significant or obviously significant differences of the intima-media thickness and plaques subsidence were found in both groups before and after treatment （P 〈 0.05）. The difference of plaques subsidence was significant between two groups after treatment （P 〈 0.05）. During the treatment, the differences of the incidences of cardiovascular event and rehospitalization were significant between two groups （P 〈 0.05）. Conclusion： Xinmaikang can decrease blood lipid levels, and can alleviate atherosclerosis.

关 键 词：动脉粥样硬化 中医治法 软坚散结法 心脉康方 

分 类 号：R543.5[医药卫生—心血管疾病]