50%硫酸镁溶液中过氧化氢稳定性的影响因素分析  

Influencing Factors of the Stability of Dioxogen in 50% Magnesium Sulfate Solution

作　　者：姚国新[1] 汤远亮[1] 孙华芳[1] 徐永祥[1] 刘治安[1] 

机构地区：[1]中山大学附属东莞东华医院药剂科,东莞市523110

出　　处：《中国药房》2011年第5期416-417,共2页China Pharmacy

摘　　要：目的:考察pH值和加入不同浓度金属离子络合物乙二胺四乙酸二钠(EDTA-Na2)对50%硫酸镁溶液中过氧化氢稳定性的影响,为过氧化氢作为防腐剂使用提供试验依据。方法:在pH值3.69、3.80、4.02、4.77、6.40、6.81和加入EDTA-Na20.01%、0.02%、0.04%、0.08%、0.16%的条件下,测定2厂家50%硫酸镁溶液中过氧化氢在贮存60d过程中的含量变化,分析pH值和EDTA-Na2对过氧化氢稳定性的影响。结果:不同pH值条件下过氧化氢贮存5d后含量均为0;加入0.04%以下浓度的EDTA-Na2贮存60d后过氧化氢含量均为0,加入0.04%以上浓度的EDTA-Na2贮存60d后过氧化氢的含量均约为50%。结论:溶液pH值对过氧化氢无稳定作用,加入EDTA-Na2对过氧化氢有一定的稳定作用。OBJECTIVE： To investigate the influence of pH value and EDTA-Na2 on the stability of dioxogen in 50% magnesium sulfate solution in order to provide reference for dioxogen being used as antiseptic. METHODS： The concentration of dioxogen in 50% magnesium sulfate solution with different pH values （3.69, 3.80, 4.02, 4.77, 6.40, 6.81） and adding 0.01%, 0.02%, 0.04%, 0.08% or 0.16% EDTA-Na2 were determined during 60 days of storage. The effects of pH value and EDTA-Na2 on the stability of dioxogen were analyzed. RESULTS： Doxogen wasn’t found at different pH value after 5 days or adding EDTA-Na2 below 0.04% after 60 days storage. The concentration of dioxogen reduced to 50% after adding EDTA-Na2 above 0.04% stored for 60 days. CONCLUSION： The pH value can hardly influence the stability. EDTA-Na2 promotes the stability of dioxogen in 50% magnesium sulfate solution.

关 键 词：过氧化氢 硫酸镁 乙二胺四乙酸二钠 PH值 稳定性 

分 类 号：R927.11[医药卫生—药学] R986