基于TCP和NTCP模型的鼻咽癌放疗的比较分析  

Comparative Analysis of Nasopharyngeal Carcinoma (NPC) Radiotherapy Based on TCP and NTCP Model

作　　者：陈海[1] 杨麟[1] 刘晓东[1] 文婷[1] 

机构地区：[1]广州军区总医院放疗科,广东广州510010

出　　处：《中国医疗设备》2011年第1期51-52,40,共3页China Medical Devices

摘　　要：目的通过作者编程实现肿瘤控制概率(TCP)和正常组织并发症概率(NTCP)模型的数值计算,实现鼻咽癌放疗的比较分析。方法选择2006～2008年40例行放射治疗的病人的治疗方案,利用Matlab分别计算TCP和NTCP,并对计算结果进行统计分析。结果常规放疗和适形放疗的TCP统计结果无差异,而在NTCP计算结果中,常规放疗的脑干以及腮腺的NTCP要高于适形放疗,尤以腮腺更为显著。结论 TCP和NTCP模型都能有效评估放射治疗计划的效果。Objective TCP and NTCP models were computed through computer programming and used for comparative analysis of nasopharyngeal carcinoma （NPC） radiotherapy.Methods TCP and NTCP models were computed with Matlab.The treatment plans of 40 NPC patients treated by radiotherapy during 2006 and 2008 were selected and their TCP and NTCP were computed and analyzed.Results The statistic results of TCP were no difference between conventional radiotherapy and 3D conformal radiotherapy,while the results of NTCP of brainstem and parotid were significant difference between the two techniques,especially the results of parotid.Conclusion TCP and NTCP model can be used to evaluate the radiotherapy plan effectively.

关 键 词：放射治疗 鼻咽癌 肿瘤控制概率(TCP) 正常组织并发症概率(NTCP) 

分 类 号：R815[医药卫生—放射医学]