社区相关的耐甲氧西林金黄色葡萄球菌毒力因子的研究进展  

Progress of virulence determinants in community-associated methicillin-resistant staphylococcus aureus

作　　者：李向梅(综述)[1] 沈叙庄(审校)[1] 

机构地区：[1]首都医科大学附属北京儿童医院儿科研究所微生物学和免疫学实验室,100045

出　　处：《国际儿科学杂志》2011年第1期26-29,共4页International Journal of Pediatrics

摘　　要：耐甲氧西林金黄色葡萄球菌（methicillin-resistant staphylococcus aureus,MRSA）是一种重要的人类病原体.过去,MRSA感染仅在医院中发生,并局限于有潜在危险因素的免疫能力减弱的个体.近年来,能引起医疗保健场所外健康人群坏死性筋膜炎甚至死亡等严重感染的社区相关的MRSA（CAMRSA）菌株正在全世界范围内流行.人们一直试图解释CA-MRSA毒力增强的原因,该文就近年来对4种毒力因子,即Panton-Valentine杀白细胞素、α-溶血素、α-型苯酚可溶解的调控蛋白、精氨酸分解代谢可动元件的研究进展作一综述.Methicillin-resistant staphylococcus aureus （MRSA） remains a prominent human pathogen.Traditionally, MRSA infections occurred exclusively in hospitals and were limited to immunocompromised patients or individuals with predisposing risk factors. However, recently there has been a worldwide epidemic caused by community-associated （CA）-MRSA strains, which can cause severe infections that can result in necrotizing fasciitis or even death in otherwise healthy children or adults outside of healthcare settings. People have made great progress to explain the reasons for enhanced virulence of CA-MRSA, here we review the recent progress made towards four virulence determinants, which are Panton-Valentine leukocidin （PVL）, α-Hemolysin （Hla）,α-type phenol-soluble modulin （ PSMα） and arginine catabolic mobile element （ACM E） .

关 键 词：社区相关的耐甲氧西林金黄色葡萄球菌 Panton-Valetine杀白细胞素 α-溶血素 α-型苯酚可溶解的调控蛋白 精氨酸分解代谢可动元件 

分 类 号：R378.11[医药卫生—病原生物学]