CD40在T细胞介导的免疫反应中的作用  

The role of CD40 in T cell-mediated immune response

作　　者：路康(综述)[1] 韩波(审校)[1] 

机构地区：[1]山东大学附属省立医院小儿心脏科,济南250021

出　　处：《国际儿科学杂志》2011年第1期41-43,共3页International Journal of Pediatrics

基　　金：山东省科技攻关计划项目（2009GG10002058）

摘　　要：CD40-CD40L共刺激信号通路的激活在T细胞介导的免疫应答反应中具有举足轻重的作用.表达于抗原递呈细胞（APC）表面的CD40通过与表达于T细胞表面的CD40L结合而发生激活,在参与诱导机体抗感染所必需的早期炎症反应的同时,还介导了自身免疫性病理损伤的发生.同时,有证据表明CD40分子也表达于T细胞,并可作为共刺激分子发挥作用.对CD40在T细胞活化中的确切机制和作用的进一步分析,有助于对器官移植排斥反应、自身免疫性疾病、肿瘤、炎性反应等疾病的治疗开辟一条新的途径.The activation of CD40-CD40L costimulatory signal channel plays a necessary role in T cellmediated immune response. Activation of CD40 on antigen presenting cells by CD40L which expressed on Tlymphocytes, while contributing to the pro-in？ ammatory response necessary for eradication of infection, accounts for the pathology in autoimmunity. Meanwhile, there is evidence that CD40 is also expressed on T-lymphocytes and can act as a costimulatory molecule. Further dissection of the exact nature and role of CD40 in T cell activation could lead the way to novel therapeutics for diseases which include organ-graft refection, autoimmune diseases,tumor, and inflammation.

关 键 词：CD40 T细胞 共刺激分子 

分 类 号：R457.7[医药卫生—治疗学]