脑缺血再灌注时40Hz AERP和听力的变化  

Changes of 40Hz Auditory Event Related Potentials and Hearing in Brain Ischemia and Reperfusion

作　　者：施宁华[1] 许燕[1] 张志坚[1] 卢步峰[1] 戴树宏[1] 迟放鲁[2] 缪川梅 

机构地区：[1]镇江医学院,212001 [2]上海医科大学附属眼耳鼻喉科医院 [3]镇江市第四人民医院耳鼻咽喉科

出　　处：《镇江医学院学报》1999年第3期340-344,共5页Journal of Zhenjiang Medical College

基　　金：江苏省教委自然科学基金!94170

摘　　要：以大鼠四动脉闭塞造成脑缺血模型研究了脑缺血和再灌注时大鼠40Hz听觉相关电位（40HzAERP）反应阈值、振幅的改变及听力的动态变化。在脑缺血早期；AERP反应阈随缺血时间的延长持续升高，缺血15、3060min与2h组阈值显著高于对照组（P＜0.01），振幅则明显降低，出现急性听力下降。再灌注初期2h听反应阈保持较高水平，与缺皿30min比较无统计学差异（P＞1.05）再灌注24、48、72h反应阈值逐渐下降，仍有明显的听力报失。再灌注7天后听阈基本恢复，但振幅下能恢复正常。结果提示40HzAERP对缺血非常敏感,脑缺血和再灌注可能导致突发性听力损伤。The brain ischemia model was established in rats by four-vessel occlusion. By applying the model, the changes of 40Hz AERP threshold and amplitude during acute brain ischemia and reperfusion and effect of brain ischemia and reperfusion on the hearing were investigated. The results showed: in early stage of brain ischemia, 40Hz AERP threshold increased continuously when the ischemic time prolonged, the threshold in 15, 30. 60min and 2h ischemic group was elevated more than that of the control group (P<0. 01 ); the amplitude was significantly decreased, there was obvious bearing loss during acute ischemia. At the initial 2h of reperfusion (after 30min ischemia), the auditory response threshold kept higher levels, the threshold had no change compared with that of 30min reperfusion (P>0. 05); in 24、48、72h of reperfusion, the AERP threshold decreased gradually. After 7day of reperfusion, the hearing threshold basically recovered, but no recovery of the amplitude was shown during reperfusion. These findings suggested that 40Hz AERP may be susceptible to brain ischemia. brain ischemia and reperfusion may induce sudden hearing loss.

关 键 词：脑缺血 再灌注 听觉相关电位 听力损伤 

分 类 号：R764.431[医药卫生—耳鼻咽喉科] R743.310.6[医药卫生—临床医学]