醋酸棉酚宫内给药装置在小鼠体内药动学研究  

Evaluation of the Release Rate of Gossypol Acetate from a Gossypol-Loaded Intrauterine Device in Mice

作　　者：裘琳[1,2] 赵轶[1] 袁弘[3] 许泓[1] 胡富强[3] 林俊[1] 张信美[1] 

机构地区：[1]浙江大学医学院附属妇产科医院,杭州310006 [2]杭州师范大学附属医院,杭州310015 [3]浙江大学药学院药物制剂研究所,杭州310058

出　　处：《中国现代应用药学》2011年第1期63-66,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省科技厅项目(2006R10027)

摘　　要：目的探索醋酸棉酚宫内给药装置在小鼠体内的药动学特征。方法将醋酸棉酚宫内给药装置放入小鼠子宫内,用HPLC测定血浆中药物浓度。结果醋酸棉酚宫内给药装置放入小鼠子宫中,体内血药浓度在48 h达到高峰(0.30μg.L-1),随后呈现恒速释放的特征。结论醋酸棉酚宫内给药装置在小鼠体内达峰时间迅速,并能长时间维持稳定的药物释放,有望用于子宫腺肌病的治疗。OBJECTIVE To explore the release rate of gossypol acetate from a designed gossypol-loaded intrauterine device（IUD） in mice.METHODS The mice were administrated with gossypol acetate-loaded IUD and then the release rate of gossypol acetate from the IUD was tested by HPLC.RESULTS The results showed that the concentration of plasma gossypol acetate gradually increased to a peak level of 0.30 μg-L-1 on the second day,which was then maintained for several months.CONCLUSION A gossypol-loaded IUD is a reliable method of administration for gossypol acetate and it is possibly an effective way to treat adenomyosis in mice.

关 键 词：醋酸棉酚 宫内给药装置 子宫腺肌病 小鼠 

分 类 号：R969.1[医药卫生—药理学]