慢性砷暴露对雌鼠血清雌二醇、孕酮水平的影响  

Effects on serum estadiol and progesterone of female mice exposed to arsenic chronically

作　　者：郭宏宇 郝光 夏雅娟 郭威 李存保[2] 郭志伟[2] 

机构地区：[1]内蒙古地方病防治研究中心,呼和浩特010031 [2]内蒙古医学院

出　　处：《卫生研究》2011年第1期120-121,共2页Journal of Hygiene Research

基　　金：国家自然科学基金项目(No.30960336)

摘　　要：目的通过观察不同水砷剂量慢性砷暴露昆明种雌鼠血清激素雌二醇、孕酮水平的变化,探讨砷的雌激素样效应。方法选择暴露于不同剂量As2O3(0、0.05、0.10、0.20和0.40μg/ml)饮水20周的昆明种雌鼠为研究对象,采用放射免疫法测定血清激素雌二醇与孕酮含量。结果慢性砷暴露雌鼠血清雌二醇和孕酮含量均有变化:与对照组比较,0.20μg/ml组(P<0.01)与0.40μg/ml组(P<0.05)雌二醇含量降低,0.10μg/ml组孕酮含量减少(P<0.01)。结论慢性砷暴露扰乱血清激素水平,砷具有雌激素效应。Objective By measure the changes of serumal estadiol and progesterone levels of kunming female mice,which are chronically exposed to different concentrations of arsenic trioxide,discuss the estrogen-like effects of arsenic.Methods Select the Kunming female mice exposed to different drinking water of arsenic trioxide（0,0.05,0.10,0.20,0.40μg /ml） for 20 weeks as the research subjects in this study.Use the method of radioimmunology to measure concentrations of serumal estadiol and progesterone of female adult mice.Results Compared with the control group,there exists the changes of the concentrations of the serumal estadiol and progesterone of Km female adult mice,which are chronically exposed to the arsenic.Compared to the control group,the differences of the concentrations of the serumal estadiol in the 0.05μg /ml group and 0.10μg /ml group have no statistical significance（P〈0.05）,the concentrations of estadiol in the 0.20μg /ml group（P〈0.01） and 0.40μg / ml group（P〈0.05） decrease.Compared to the control group,the differences of the concentrations of the serumal progesterone in the 0.05μg /ml group,0.20μg /ml group and 0.40μg /ml group have no statistical significance（P〈0.05）,the concentration of serumal progesterone in the 0.10μg /ml group（P〈0.01） decrease.Conclusion Chronically arsenic exposure can interfere the levels of serumal hormones.Arsenic has the estrogen-like effects.

关 键 词：砷 雌激素样效应 雌二醇 孕酮 

分 类 号：R994.6[医药卫生—毒理学] R599[医药卫生—药学]