黄芩类药物与人血清白蛋白的相互作用  

Interaction Between Scutellaria baicalensis Georgi and Human Serum Albumin

作　　者：王宁[1,2] 刘忠英[1] 胡秀丽[1] 卜凤泉[1] 赵学忠[3] 

机构地区：[1]吉林大学药学院,长春130021 [2]吉林省人民医院肾脏内科,长春130021 [3]吉林大学白求恩第一医院心血管内科,长春130021

出　　处：《高等学校化学学报》2011年第2期241-245,共5页Chemical Journal of Chinese Universities

摘　　要：利用荧光猝灭技术和紫外-可见分光光度法研究了黄芩苷和汉黄芩苷与人血清白蛋白的结合性质,由药物对血清白蛋白的荧光猝灭作用求出其结合常数.根据热力学参数确定了结合力的性质,并进一步研究了Zn2+,Mg2+,Al3+和Cu2+存在时对结合性质的影响.此研究不仅对于揭示体内药物动力学问题和指导临床合理用药具有一定意义,而且对药物分子设计及新药开发等也具有重要指导意义.The interactions of baicalin and wogonoside with human serum albumin（HSA） were studied by fluorescence quenching and ultraviolet-visible absorption spectrometry.The binding constants were obtained by fluorescence quenching of drug with serum albumin.The main acting binding forces of baicalin and wogonoside to serum albumins were hydrophobic force according to the thermodynamic parameters.The effects of me-{tal} ions,such as Zn2＋,Mg2＋,Al3＋ and Cu2＋on binding constants were also evaluated.It is not only valuable to reveal the pharmacokinetics,clinical therapy,but also guiding significance for drug design and development of new drugs.

关 键 词：黄芩苷 汉黄芩苷 人血清白蛋白 荧光猝灭 

分 类 号：O657[理学—分析化学]