补肾壮骨冲剂对更年期综合征患者性激素及血脂的影响  

Effect of Bushen Zhuanggu Granules upon Gonadal Hormone and Blood Fat in Climacteric Females

作　　者：邓伟民[1] 黄海[1] 曾东[1] 李晓昊[1] 张金玉[1] 邵玉[1] 周丽[1] 黄伟毅[1] 韩丽萍[1] 

机构地区：[1]中国人民解放军广州军区广州总医院华侨科

出　　处：《中医杂志》2011年第3期208-210,213,共4页Journal of Traditional Chinese Medicine

基　　金：广东省中医药管理局资助课题(20601240102151);广东省科技计划项目(2008B040200019)

摘　　要：目的观察补肾壮骨冲剂对更年期综合征患者性激素及血脂的影响。方法将582例患者随机分为中药组285例和西药组297例。中药组口服补肾壮骨冲剂治疗,西药组应用倍美力加安宫黄体酮治疗。主要观察治疗前后血脂[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、性激素[雌二醇(E2)、卵泡刺激激素(FSH)、促黄体生成素(LH)]等指标及症状体征积分的变化。结果中药组治疗半年后脱失63例;西药组治疗脱失94例,两组比较有统计学差异(P<0.01)。中药组总有效率82.87%,西药组总有效率73.12%,两组比较有统计学差异(P<0.01)。两组治疗后症状总评分较治疗前均有明显减少(P<0.05或P<0.01),并且中药组优于西药组(P<0.01)。两组治疗前后性激素水平和血脂比较差异有统计学意义(P<0.05)。结论补肾壮骨冲剂治疗更年期综合征患者,能纠正血脂紊乱、性激素各项指标,疗效与雌激素替代疗法相当,且无副作用。Objective To observe the effect of Bushen Zhuanggu Granules （Herbal granules for reinforcing kidney to strengthen bones） upon gonadal hormone and vasomotor symptoms of climacteric females. Methods Totally 582 postmenopausal outpatients were randomized into Chinese medicine group of 285 cases and western drug group of 297 cases. The Chinese medicine group was treated with Bushen Zhuanggu Granules and the western drug group was with premarin and provera. The main observed indices were blood fat including total cholesterol （TC）,triglyceride （TG）,high density lipoprotein cholesterol （HDL-C）,and low density lipoprotein cholesterol （LDL-C）,gonadal hormones including estradiol （E2）,follicle stimulating hormone （FSH）,and luteinizing hormone （LH）,and the changes in scores of symptoms and signs before and after treatment. Results There were 63 dropouts in the Chinese medicine group after a half-year’s treatment,and 94 dropouts in the western drug group,the difference between the two groups was significant （P〈0.01）. The total effective rate of the Chinese medicine group was 82.87%,while that of the western drug group was 73.12%,there was significant difference between the two groups after treatment （P〈0.05）. The total symptom score of both groups was significantly decreased after treatment （P〈0.05 or P〈0.01）,but the Chinese medicine group was superior to the western drug group （P〈0.01）. Changes of gonadal hormone and blood fat of both groups after treatment was significant,showing a statistical difference （P〈0.05）. Conclusion Bushen Zhuanggu Granules can effectively regulate gonadal hormone and blood fat in climacteric females,with a similar function of western estrogen replacement therapy,but without untoward effect.

关 键 词：绝经后期 补肾健脾化瘀法 脂类 雌二醇 

分 类 号：R271.9[医药卫生—中西医结合]