VDR基因多态性与环境交互作用对体能影响  

Interactive effect of vitamin D receptor gene polymorphism and environmental factors on physical development among adolescents

作　　者：胡明月[1] 李嫱[2] 包其郁[2] 杨新军[1] 丁力[1] 

机构地区：[1]温州医学院环境与公共卫生学院预防医学系,浙江温州325035 [2]温州医学院分子生物学研究中心

出　　处：《中国公共卫生》2011年第2期219-220,共2页Chinese Journal of Public Health

基　　金：浙江省医药卫生科研基金项目(2007B134);浙江省温州市科技局科研基金项目(Y20070054)

摘　　要：目的探讨维生素D受体(VDR)基因遗传多态性与环境交互作用对青少年体能发育影响。方法随机抽取浙江省绍兴市17～18周岁青少年212名进行体格检查及问卷调查,对VDR基因进行PCR扩增,采用基因测序技术检测基因多态性,以多分类有序Logistic模型分析体能发育的影响因素和交互作用。结果维生素D受体基因Bs-mI位点的多态性与体育锻炼存在交互作用,交互作用系数为3.208;Tru9I位点的多态性与体育锻炼、睡眠时间以及学校对体育锻炼的重视等均存在交互作用,交互作用系数分别为2.499、1.936和1.987。结论青春期体能发育中,维生素D受体基因多态性与环境因素存在交互作用。Objective To investigate interactive effect of vitamin D receptor（VDR） gene polymorphism and environment factors on physical development among adolescents.Methods Totally 212 adolescents at age of 17 to 18 years were randomly selected from senior high schools of Shaoxing city for physical examination and questionnaire survey.Polymerase chain reaction（PCR） and DNA sequencing were performed to analyze the VDR genotype.The relationship between VDR gene polymorphism and environmental factors on physical development was analyzed with ordinal logistic regression analysis.Results The results showed that the interactive effect existed in BsmI gene site polymorphism and physical exercise with an interaction index value of 3.208.The interactive effect existed in Tru9I gene site polymorphism and physical exercise,sleeping time,the importance of physical exercise advocated by the school with the interaction index value of 2.499,1.936,and 1.987,respectively.Conclusion VDR gene polymorphism and environment factors show an interactive effect on physical development among adolescents.

关 键 词：维生素D受体 基因多态性 环境因素 交互作用 体能 

分 类 号：R179[医药卫生—妇幼卫生保健]