夏天无总碱多囊脂质体的制备与体外特征评价  

Preparation and in Vitro Evaluation of Corydalis decumbens Total Alkali Multivesicular Liposomes

作　　者：刘芬[1] 李良[2] 钟海军[1] 黄惠明[1] 郭峰[1] 徐春莲[1] 徐卫国 

机构地区：[1]南昌大学医学院药学系,南昌市330006 [2]武警江西总队医院药剂科,南昌市330001 [3]江西天施康中药股份有限公司,鹰潭市335000

出　　处：《中国药房》2011年第7期605-607,共3页China Pharmacy

基　　金：江西省科技计划工业领域重点项目(2007BG13105)

摘　　要：目的:制备夏天无总碱多囊脂质体,并进行体外特征评价。方法:以包封率为评价指标,以卵磷脂(PC)与药物、PC与三油酸甘油酯(TO)、PC与磷脂酰丝氨酸(PS)、PC与胆固醇(CH)的质量比为考察因素,用复乳法制备夏天无总碱多囊脂质体;并考察其形态、粒径和体外释放行为。结果:PC与药物、PC与TO、PC与PS、PC与CH的质量比分别为10∶2、3∶1、4∶3、1∶2.5,包封率可达(50±3)%;多囊脂质体呈球状体,平均粒径为22.0μm,在生理盐水中体外释放时间可持续2d。结论:该制备工艺稳定、可行。OBJECTIVE： To prepare Corydalis decumbens total alkali multivescular liposomes and evaluate it in vitro. METHODS： C. decumbens total alkali multivescular liposomes were prepared by multiple emulsion method with encapsulation efficiency as index and with ratio of phospgatidycholine （PC） to drugs, ratio of PC to triolein （TO）, ratio of OC to phosphatidylserine （PS） and ratio of PC to cbolesterin （CH） as factors. The morphology, particle size, release in vitro of preparation were evaluated. RESULTS： The ratio of PC to drug, ratio of PC to TO, ratio of PC to PS and ratio of PC to CH were 10 ： 2,3 ： 1,4 ： 3, 1 ： 2.5. The encapsulation efficiency of optimized formulation was （50±3）%. The multivescular liposomes assumed as spherical with average particle diameter of 22.0μm. The drug release duration in normal saline was 2 days. CONCLUSION： The preparation technology is stable and feasible.

关 键 词：夏天无总碱 多囊脂质体 制备 体外评价 缓释 

分 类 号：R283.69[医药卫生—中药学] R284[医药卫生—中医学]