阿克他利大鼠在体肠吸收动力学  

Intestinal absorption kinetics of actarit in rats

作　　者：范景新[1] 张文骥[1] 颜廷旭[1] 惠颖[1] 聂淑芳[1] 潘卫三[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2011年第2期144-147,共4页Journal of Shenyang Pharmaceutical University

摘　　要：目的研究阿克他利大鼠在体肠吸收动力学特征。方法采用大鼠在体单向灌流法进行肠吸收实验,以吸收速率常数(ka)和表观吸收系数(Papp)为指标,从灌流速度、药物浓度和吸收部位3个方面对阿克他利肠吸收动力学特征进行考察。结果不同灌流速度下的ka和Papp有极其显著性差异(P<0.01);药物浓度在一定范围内对ka和Papp无显著性影响(P>0.05);小肠各段(十二指肠、空肠、回肠)的ka和Papp无显著性差异(P>0.05);小肠与结肠的ka存在极其显著性差异(P<0.01),Papp存在显著性差异(P<0.05)。结论阿克他利在整个肠道吸收良好,但吸收窗主要在小肠,在结肠段的吸收相对较差。Objective To study the in vivo intestinal absorption kinetics of actarit in rats. Methods Singlepass perfusion method was adopted to investigate the influence of three factors, including perfusion rate, drug concentration and absorption site, on the in vivo intestinal absorption kinetics of actarit. The indicators were absorption rate constant（ ka ） and apparent absorption coefficient（ Papp ）. Results Perfusion rate could significantly affect k, and Papp （ P 〈 0.01 ）. Drug concentration had little effects on ka and Papp （ P 〉 0. 05 ）. k, and Papp values of intestinal sections （ duodenum, jejunum and ileum ） showed no significant difference （ P 〉 0. 05 ）. However, ka values between small intestine and colon had highly significant difference （P 〈 0. 01 ）, and Papp values between them were significantly different（ P 〈0.05 ）. Conclusions Actarit can be easily ab- sorbed in general intestinal segments, but the absorption window is mainly in the small intestine, and the ab- sorption in the colon segment is relatively poor.

关 键 词：阿克他利 单向灌流法 在体肠吸收 吸收速率常数(ka) 表观吸收系数(Papp) 

分 类 号：R971[医药卫生—药品]