接骨木中的五个木脂素和一个环烯醚萜(英文)  

Five Lignans and an Iridoid from Sambucus williamsii

作　　者：欧阳富[1] 刘远[1] 李荣[1] 李玲[2] 王乃利[1,2] 姚新生[1] 

机构地区：[1]沈阳药科大学中药学院,沈阳110016 [2]深圳清华大学研究院深圳中药及天然药物研究中心,深圳518057

出　　处：《中国天然药物》2011年第1期26-29,共4页

基　　金：国家自然科学基金委员会与香港研究资助局联合基金(No. 30418007)~~

摘　　要：目的:研究接骨木Sambucus williamsii Hance茎枝的化学成分。方法:采用60%乙醇提取,经D101大孔吸附树脂、硅胶和ODS等柱色谱以及制备型HPLC等各种现代分离手段,对接骨木茎枝中的化学成分进行分离纯化,并用光谱学方法对得到的化合物进行结构鉴定。结果:分离得到了5个木脂素类和1个环烯醚萜类化合物,分别是 dehydrodiconiferyl alco-hol-4-O-β-D-glucopyranoside(1),dihydrodehydrodiconiferyl alcohol-4-O-β-D-glucopyranoside(2),(7S, 8R)-dihydro-3'-hydroxy-8-hydroxy-methyl-7-(4-hydroxy-3-methoxy-phenyl)-1'-benzofuranpropanol(3),erythro-1-(4-hydroxy-3-methoxyphenyl)-2-[2-hydroxy-4-(3-hydroxypropyl)phenoxy]-1,3-propanediol(4),threo-1-(4-hydroxy-3-methoxyphenyl)-2-[2-hydroxy-4-(3-hydroxypropyl)phenoxy]-1,3-propanediol(5),莫诺苷(6)(其中α-莫诺苷大约占70%,β-莫诺苷占 30%)。结论:化合物1、4、5为首次从该属植物中分离得到,化合物2、3、6为首次从该植物中分离得到。AIM：To study the chemical constituents of the 60% ethanol extract of the stems of Sambucus williamsii Hance.METHODS：Compounds were isolated and purified by macroporous adsorptive resin D101,silica gel,and ODS column chromatographies and preparative HPLC.Their structures were identified by spectroscopic methods.RESULTS：Five lignans and one iridoid were isolated from the stems of Sambucus williamsii Hance.and their structures were identified as dehydrodiconiferyl alcohol-4-O-β-D-glucopyranoside （1）,dihydrodehydrodiconiferyl alcohol-4-O-β-D-glucopyranoside （2）,（7S,8R）-dihydro-3＇-hydroxy8-hydroxy-methyl-7-（4-hydroxy-3-methoxy-phenyl）-1＇-benzofuranpropanol （3）,erythro-1-（4-hydroxy-3-methoxyphenyl）-2-[2-hydroxy-4-（3-hydroxypropyl） phenoxy]-1,3-propanediol （4）,threo-1-（4-hydroxy-3-methoxyphenyl）-2-[2-hydroxy-4-（3-hydroxypropyl） phenoxy]-1,3-propanediol （5）,and morroniside （6） with about 70% α-morroniside and 30% β-morroniside.CONCLUSION：Compounds 1,4 and 5 were isolated from this genus for the first time,and compounds 2,3 and 6 were obtained from the plant for the first time.

关 键 词：接骨木 木脂素 环烯醚萜 莫诺苷 

分 类 号：R284.1[医药卫生—中药学]