聚焦超声治疗前后外阴白色病变组织中VEGF、bFGF和CD34表达的检测及其意义  

Determination of expressions of VEGF,bFGF and CD34 in vulvar white lesion tissues before and after focusing ultrasound therapy and its significance

作　　者：高建宏[1] 高金荣[1] 杨雅琴[1] 左志洪[1] 蒙晓玲[1] 贾俊茹[1] 

机构地区：[1]河北省廊坊市人民医院妇产科,河北廊坊065000

出　　处：《吉林大学学报（医学版）》2011年第1期130-133,I0003,I0004,共6页Journal of Jilin University：Medicine Edition

基　　金：河北省科技厅指导项目资助课题(2005)

摘　　要：目的:探讨VEGF、bFGF和CD34在聚焦超声治疗前后的外阴白色病变组织中表达率的变化情况,阐明聚焦超声治疗外阴白色病变的可能机制。方法:采取免疫组织化学SP法检测30例外阴白色病变组织、15例经聚焦超声治疗后1个月和8例治疗后3个月外阴白色病变患者病变组织中VEGF、bFGF和CD34的表达情况,比较三者在治疗前后的阳性细胞表达率。结果:聚焦超声治疗后VEGF和bFGF在外阴白色病变组织中的表达高于治疗前(P<0.05);聚焦超声治疗前后CD34在外阴白色病变组织中的表达差异无统计学意义(P>0.05)。结论:聚焦超声治疗可使外阴白色病变组织中VEGF和bFGF的表达升高,其机制可能是通过改善外阴白色病变局部组织神经微血管结构和功能使外阴白色病变组织恢复至正常。Objective To study the changes of the expressions of VEGF,bFGF and CD34 in vulvar white lesion tissues before and after focusing ultrasound therapy and clarify the mechanism of focusing ultrasound in treatment of vulvar white lesion.Methods The expressions of VEGF,bFGF and CD34 in 30 cases of vulvar white lesion tissues,15 cases one month after treatment and 8 cases three months after treatment were detected by SP immunohistochemistry method.The positive expressions of VEGF,bFGF and CD34 in vulvar white lesion tissues in three groups before and after treatment were compared.Results The expressions of VEGF and bFGF in vulvar white lesion tissues after treatment were higher than before treatment（P0.05）.The expression of CD34 in vulvar white lesion tissues had no significant difference between before and after treatment（P0.05）.Conclusion Focusing ultrasound therapy could increase the expressions of VEGF and bFGF in vulvar white lesion tissues and improve the structure and function of nerve and capillary.

关 键 词：高强度聚焦超声 外阴白色病变 血管内皮细胞生长因子 碱性成纤维细胞生长因子 CD34 

分 类 号：R711.72[医药卫生—妇产科学] R358.1[医药卫生—临床医学]