关于假基因的研究进展  

On Research Progress of Pseudogene

作　　者：崔峰[1] 夏家辉[1] 

机构地区：[1]湖南医科大学医学遗传学国家重点实验室,中国湖南长沙410078

出　　处：《生命科学研究》1999年第3期203-209,共7页Life Science Research

基　　金：国家自然科学基金

摘　　要：随着人类基因组计划不断深入，对于占人类基因组 ９７％ 的非表达序列的研究也逐渐成为热点⒚在基因克隆和基因表达研究的过程中，返座假基因是我们经常碰到的问题⒚本文不仅对返座假基因的结构特征进行了小结，并且对返座假基因编码潜能、返座机理以及在进化过程中的作用进行了综述。Non expression sequence which comprises of 97% of human genome has been becoming one of the “hotspots” in the deepening and widening of “Human Genome Project”. Retropseudogenes is one of the problems we encounter repeatedly in process of gene cloning and expression. This paper not only makes a summary for the structure characteristics of retropseudogenes, but also reviews the coding potentials, retroposition mechanism and the role in evolution. The research progress and developing prospects in this area is also reported.

关 键 词：返座假基因 结构特征 返座机理 

分 类 号：Q754[生物学—分子生物学]