山莨菪碱作为常规药治疗毒蛇咬伤的研究报告(英文)  

Report of Anisodamine as a Routine Drug to Treat Snakebites

作　　者：李其斌[1] 林可干 潘磊[1] 王桂芬 汤圣希[3] 

机构地区：[1]广西医科大学第一附属医院急诊科,南宁530021 [2]中国蛇协急危重症医学研究所,南宁5300213 [3]广西医科大学蛇毒研究所,南宁530021

出　　处：《蛇志》1999年第3期6-8,共3页Journal of Snake

摘　　要：山莨菪碱是我国首先从茄科植物唐古特莨菪中分离出的一种生物碱， 是改善微循环衰竭的一种特效药物， 特别是在防治蛇伤 Ｄ Ｉ Ｃ或急性肾衰的病例往往收到意想不到的好结果， 另外， 该药在抢救过程中大剂量 ５００ｍ ｇ／ｄ（是普通剂量１０ｍ ｇ 的 ５０ 倍） 使用而未见明显副作用， 因此， １９８７ 年以来我们常规使用山莨菪碱治疗 （重症者配合抗蛇毒血清） 各种毒蛇咬伤７９７ 例， 均收到明显效果， 认为山莨菪碱是防治蛇伤血液毒引起 Ｄ Ｉ Ｃ 出血、急性肾衰、微循环衰竭、 Ｍ Ｓ Ｏ Ｆ的有效药物， 并可减轻神经毒引起的气道分泌物阻塞、提高血氧分压， 减轻缺氧对大脑的损害，竟争保护胆碱能受体、减轻神经毒性、加快自主呼吸恢复的功能。Anisodamine is a natural alkaloid drug isolated from the plant of Anisodus tanguticus growing in western China The chemical structure and pharmacological action are just like the cholinergic receptor blocking agents atropine or scopolamine The specific characteristic of the drug is being able to relieve the dangerous situation of microcirculatory failure,especially in case of acute DIC or renal failure The prognosis of the patients will be quite unexpectedly fine in the result Another characteristic of the drug is that no serious toxic reaction occurs even in successive doses given intravenously up to 500mg a day This is about fifty times greater than a common dose 10mg Since 1987 we begin with the drug as a routine medication for the symptomatic treatment of 797 cases of poisonous snakebites, special in the renal failure, DIC bleeding and microcirculatory failure of snakebites,we should say that the specific antivenin and anisodamine are two treasure drugs for snakebites In other hand, anisodamine can diminish the oversecretion of respirator tract, increse the PO 2 of blood and decrese the severity of brain damage, and compete against α neurotoxin of snake venom in connection with cholinergic receptor and shorten the period of recover time to resume the spontaneous breathing

关 键 词：山莨菪碱 蛇咬伤 微循环衰竭 药物疗法 

分 类 号：R646.05[医药卫生—外科学]