金不换鲜三七液对哺乳动物致突变和致畸安全性评价  

AN EVALUATION OF SECURITY FOR KINGPANAX FRESH Panax notoginseng JUICE IN MUTAGENIC AND TERATOGENIC TESTS OF MAMMAL

作　　者：郑文康[1] 张云生 贺维顺[3] 刘爱华[3] 王蕊芳[3] 林世英[3] 侯意谛 

机构地区：[1]云南省卫生防疫站,昆明650022 [2]云南金不换集团有限公司,昆明650000 [3]中国科学院昆明动物研究所,昆明650223

出　　处：《Zoological Research》1999年第5期321-326,共6页动物学研究（英文）

摘　　要：研究了金不换鲜三七液特殊毒理学效应的致突变性。以小鼠骨髓细胞染色体畸变试验、小鼠睾丸减数分裂染色体畸变及小鼠致畸试验为指标， 研究金不换鲜三七液的安全性。结果： （ａ） 小鼠骨髓细胞染色体畸变试验： 低、中、高３ 个剂量组小鼠骨髓细胞染色体畸变率分别为０－７ ％ 、０－２％ 和０－９ ％ ， 与对照组相比无显著差异。阳性对照组染色体畸变率大大增高。（ｂ） 小鼠睾丸减数分裂细胞染色体畸变： 在本实验条件下， 小鼠睾丸细胞染色体畸变率［ 包括性染色体单价体（Ｘ－ ＹＵ） ， 常染色体单价体（ＡＵ）］ 在各实验组和对照组之间无显著差异。（ｃ） 小鼠致畸试验： 小鼠口服金不换鲜三七液的累积剂量达１５ ｇ／ｋｇ 体重的１／１０、１／５ 和１／２ ， 小鼠致畸试验也无显著差异。实验结果表明， 金不换鲜三七液安全无毒。This paper was to investigate the mutagenicity of KINGPANAX fresh Panax notoginseng juice.We used chromosomal aberration test of bone marrow cells in mice,chromosomal aberration test in mouse testicle meiotic cells and teratogenicity test in mice as an indicater to study the securities of KINGPANAX fresh Panax notoginseng juice.The results were as follows:(a) Chromosomal aberration of bone marrow in mice:Frequency of chromosomal aberration of bone marrow in mice in the control group was 0 8%,the frequencies of low,middle and high dose groups were 0 7%,0 2% and 0 9% respectively.In comparison with control group,there was no significant difference,More significant increase of frequency of chromosomal aberration were found in positive control group.(b) Chromosomal aberration in mouse testicle meiotic cells:Under our experimental conditions,frequency of chromosomal aberration in mouse testicle meiotic cells (including sex chromosomal univalents [X-YU],autosomal univalents [AU] showed no obvious difference among various experimental groups and control group.(c) Teratogenicity test in mice:The accumulative doses of KINGPANAX fresh Panax notoginseng juice in mice by gastric instillation reached 1/10,1/5 and 1/2 of 15?g/kg body weight.No statistically significant difference in the mouse teratogenicity test was observed.According to our exparimental results,KINGPANAX fresh Panax notoginseng juice is safe for drinking and has no poisonous side effect.

关 键 词：金不换鲜三七液 安全性评价 骨髓细胞 

分 类 号：R285.1[医药卫生—中药学]