Polyethylene glycol(PEG-400):An efficient and recyclable reaction medium for the synthesis of novel 1,5-benzodiazepines and their antimicrobial activity  

作　　者：Shankaraiah G.Konda Baseer M.Shaikh Sanjay A.Chavan Bhaskar S.Dawane 

机构地区：[1]Organic Research Laboratory,Department of Chemistry Yeshwant Mahavidyalaya,Nanded-431602(M.S) India

出　　处：《Chinese Chemical Letters》2011年第1期65-68,共4页中国化学快报（英文版）

摘　　要：A new series of imidazole-containing 1, 5-benzodiazepines have been synthesized by the condensation of chalcones with o- phenylenediamine using piperidine in polyethylene glycol （PEG-400） as an efficient and green reaction solvent. The advantages of this protocol are environmental friendliness, easy work-up, high yields, mild reaction condition and avoidance of expensive catalyst. Furthermore, newly synthesized compounds were evaluated for their antimicrobial activity.A new series of imidazole-containing 1, 5-benzodiazepines have been synthesized by the condensation of chalcones with o- phenylenediamine using piperidine in polyethylene glycol （PEG-400） as an efficient and green reaction solvent. The advantages of this protocol are environmental friendliness, easy work-up, high yields, mild reaction condition and avoidance of expensive catalyst. Furthermore, newly synthesized compounds were evaluated for their antimicrobial activity.

关 键 词：PEG-400 Chalcones： o-Phenylenediamine 1 5-Benzodiazepines： Antimicrobial activity 

分 类 号：O631.3[理学—高分子化学]