DNA cleavage mediated by water-soluble manganese corrole  

作　　者：Jun Lu Hai Yang Liu Lei Shi Xiang Li Wang Xiao Ying Lei Zhang Liang Nian Ji Lin Quan Zang Chi K. Chang 

机构地区：[1]College of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China [2]Department of Applied Physics, South China University of Technology, Guangzhou 510641, China [3]State Key Laboratory of Optoelectronics Materials and Technologies/MOE Laboratory of Bioinorganic and Synthetic Chemsitry, Sun Yat-Sen University, Guangzhou 510275, China [4]Departmentt of Pharmacology, Guangdong Pharmaceutical University, Guangzhou 510006, China [5]Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA

出　　处：《Chinese Chemical Letters》2011年第1期101-104,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.20771039,20871122, 20971046);National Key Foundation Research Development Project(973)Item of China(No.2007CB815306)

摘　　要：The DNA nuclease-like activity of a water soluble manganese corrole 5, 10, 15-tris（N-methyl-4-pyridyl）- corrolatomanga- nese（III） （MnⅢTMPyC） has been investigated. MnⅢMPyC may bind strongly to DNA via outside groove binding mode as indicated by absorption spectra, viscosity measurements and CD spectra. MnInTMPyC exhibited excellent catalytic activity in the DNA oxidative cleavage in the presence of hydroperoxide.The DNA nuclease-like activity of a water soluble manganese corrole 5, 10, 15-tris（N-methyl-4-pyridyl）- corrolatomanga- nese（III） （MnⅢTMPyC） has been investigated. MnⅢMPyC may bind strongly to DNA via outside groove binding mode as indicated by absorption spectra, viscosity measurements and CD spectra. MnInTMPyC exhibited excellent catalytic activity in the DNA oxidative cleavage in the presence of hydroperoxide.

关 键 词：CORROLE MANGANESE DNA Oxidative cleavage 

分 类 号：O614.711[理学—无机化学] TQ460.35[理学—化学]