白细胞介素13基因多态性与慢性阻塞性肺病肺功能的关系  

Relationship between interleukin-13 gene polymorphism and pulmonary function in chronic obstructive pulmonary disease patients

作　　者：王伟[1] 徐敏 钱冉[1] 余亚娟[1] 梅武轩[1] 

机构地区：[1]咸宁学院临床医学院内科教研室,437100 [2]湖北省鄂州市鄂钢医院妇产科,436000

出　　处：《免疫学杂志》2011年第1期58-60,共3页Immunological Journal

基　　金：咸宁学院校级科研项目(KY09098)

摘　　要：目的研究白细胞介素13(IL-13)基因多态性与慢性阻塞性肺病(COPD)患者肺功能的关系。方法采用聚合酶链反应--限制性酶切片段长度多态性(PCR-RFLP)方法检测92例COPD患者IL-13基因+2044位点单核苷酸多态性,测定COPD患者肺功能,分析IL-13基因+2044位点多态性与肺功能的关系。结果 IL-13基因+2044位点基因型频率为G/G型48.9%、G/A型45.7%、A/A型5.4%,G/G型患者肺功能FEV1和FEV1/FVC(%)明显低于G/A型和A/A型(P<0.05)。结论 IL-13基因+2044位点多态性与COPD患者肺功能有关,G/G型COPD患者肺功能损害更加严重。The aim of our study is to investigate the relationship between interleukin-13（IL-13） gene polymorphism and pulmonary function in chronic obstructive pulmonary disease（COPD） patients.In 92 COPD patients,we examined the single nucleotide polymorphism of IL-13 gene at ＋2044 site by using polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） and tested pulmonary function,to analyze association between IL-13 gene polymorphism at ＋2044 site and the pulmonary function of COPD patients.At ＋2044 site,the genotype frequencies of G/G,G/A,and A/A were 48.9%,45.7%,and 5.4% respectively.FEV1 and FEV1/FVC of patients with G/G genotype were significantly lower than that of patients with G/A or A/A genotypes（P〈0.05）.The results showed that IL-13 gene polymorphism at ＋2044 site is associated with pulmonary function in COPD patients.Furthermore,COPD patients with G/G genotype have worse lung function than any other patients with G/A and A/A genotypes.

关 键 词：白细胞介素13 基因多态性 慢性阻塞性肺病 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]