TCR信号与免疫应答/耐受的关系  

TCR signaling and immune response/tolerance

作　　者：罗晶[1] 李欣[1] 刘燕明[2] 

机构地区：[1]长春中医药大学,130117 [2]天津中医药大学,300193

出　　处：《免疫学杂志》2011年第1期86-89,共4页Immunological Journal

基　　金：吉林省教育厅基金(吉教科合字[2008]第76号)

摘　　要：近年来关于TCR信号及其调控的研究表明,单一T细胞可借助不同信号调控区分"自己/非己"或"刺激/非刺激"。经阳性选择("自己"MHC分子教育)存活的克隆T细胞结合"自己/非刺激"MHC分子提呈的抗原肽,形成识别的单体模式,并导致耐受;也可以结合"非己/刺激"MHC分子提呈的抗原肽,形成识别的双体模式,并导致应答。即适应性免疫可调节或控制外周新现抗原的浓度,并提示免疫自稳而非免疫防御可能是其原始功能。Recent reports on the TCR singling show that a single clone of T cells can distinguish ＇self＇ from ＇non-self＇ or ＇antagonist＇ from ＇agonist＇ through different signaling regulations when their TCRs engage the antigen peptide bound to MHC molecule（pMHC）.After the positive selection（＇self＇ MHC education）,a single T cell can recognize ＇self＇ MHC molecule carried peptide by homotype recognition pattern,forming the monomer recognizing model as ＇antagonist＇ recognition,and will induce immune tolerance or anergy.The T cell may also recognize ＇non-self＇ MHC molecule carried peptide by heterotype recognition pattern,to form the dimer recognizing model as ＇non-self＇ or ＇agonist＇ recognition,and will induce immune response.These mechanisms can regulate or control the quantity of emerging antigens in the peripheral of the body and imply that the immune homeostasis,rather than the immune defense,may be the original function of the adaptive immunity.

关 键 词：TCR信号 MHC分子 应答耐受 免疫自稳 抗感染免疫 

分 类 号：R392.12[医药卫生—免疫学]