DAD1和AIF-1细胞因子在鱼类中的研究进展  

Cytokines of defender against cell death 1 and allograft inflammatory factor-1 with regard to innate immunity of fish

作　　者：王利[1] 吴信忠[2] 

机构地区：[1]西南民族大学生命科学与技术学院动物遗传与育种学国家民委–教育部重点实验室,四川成都610041 [2]浙江大学动物科技学院,浙江杭州310029

出　　处：《中国水产科学》2011年第1期237-242,共6页Journal of Fishery Sciences of China

基　　金：西南民族大学中央高校基本科研业务费专项资金资助项目(10NZYZJ02)

摘　　要：细胞因子是一类由多种细胞合成或分泌的可溶性蛋白与多肽物质,具有调节多种细胞生理功能的作用。抗细胞凋亡因子(DAD1)是一种内源性细胞凋亡抑制基因。同种移植炎症因子(AIF-1)是一种由干扰素γ诱导的钙离子结合蛋白。本文概述了DAD1和AIF-1的结构特点、功能表达、生物学作用及在水产动物中的最新研究进展,旨在为水产动物细胞因子的研究和有效应用提供参考资料。Cytokines are some of low molecular weight proteins that serve as chemical messengers in the innate and adaptive immune systems of organisms.Defender against cell death 1（DAD1） is likely to be involved in programmed cell death,which is an integral part of growth and development in multi-cellular organisms and is involved in response to a range of internal and external stimuli.Allograft inflammatory factor-1（AIF-1） is an interferon（IFN）-Q-inducible Ca2＋ binding protein.AIF-1 plays an important role in the survival and pro-inflammatory activity of macrophages and disintegrin.This paper reviews the advance in the research of functions and structures of DAD1 and AIF-1 and current research progress of the two cytokines in fish.We put forward the outlook with regard to innate immunity of fish and new direction in the future research of fish AIF-1 and DAD1.

关 键 词：抗细胞凋亡因子 同种移植炎症因子 鱼类 

分 类 号：S94[农业科学—水产养殖]