螨脱敏治疗变应性结膜炎的观察  

Clinical observation of desensitization therapy for dust mites allergic conjunctivitis

作　　者：杨瑞明[1] 沙翔垠[1] 赖荷[1] 陈卫芳[1] 谭颖谦[1] 曾明兵[1] 罗春云[1] 

机构地区：[1]广州医学院第二附属医院眼科,广州510260

出　　处：《中国实用眼科杂志》2011年第1期44-47,共4页Chinese Journal of Practical Ophthalmology

基　　金：广东省科技计划基金资助项目（20108031600139）

摘　　要：目的 观察尘螨变应原疫苗治疗变应性结膜炎的效果.方法 采用病例自身对照的方法,比较2002～2007年间122例尘螨过敏的变应性结膜炎患者在脱敏治疗前后眼痒、眼充血的评分,比较血清尘螨特异性IgE及EOS水平.结果 122例患者完成脱敏治疗并进行了治疗前后相关指标的检测.眼痒积分由（2.2±1.1）降至（0.5±0.3）（P〈0.01）,眼充血由（1.8±0.9）降至（0.4±0.3）（P〈0.01）;血清尘螨slgE及EOS由治疗前的（41.01±6.96）KUA/L、（0.698±0.378）×10^9/L,分别降至（32.06±2.98）KUA/L（P〉0.05）、（0.119±0.127）×10^9/L（P〈0.01）.临床完全控制率64.75%,良好控制率31.97%.122例中有8例出现轻度局部不良反应,2例出现全身不良反应.结论 尘螨过敏的变应性结膜炎患者进行尘螨特异性脱敏治疗是一种有效、安全的治疗方法.Objective To evaluate the effect of desensitization therapy for the dust mites allergic conjunctivitis. Methods From 2002 to 2007, prospective and case controlled trial was designed to compare the scores of ocular itch and ocular hyperemia, levels of serum specific IgE and EOS before and after desensitization therapy of the 122 dust mites allergic conjunctivitis. Results There were 122 patients completed the therapy and in compliance with the evaluations. The scores of ocular itch decreased from （2.2± 1.1） before therapy to （0.5± 0.3） after therapy （P 〈0.01）, ocular hyperemia decreased from （1.8± 0.9） before therapy to （0.4± 0.3） after therapy （P 〈0.01）; levels of serum specific IgE of dust mites and EOS decreased from （41.01±6.96） KUA/L, （0.698± 0.378）× 10^9/L to （32.06± 2.98） KUA/L（P〉0.05）, （0.119± 0.127） × 10^9/L（P〈0.01） respectively before and after therapy. 64.75% of the patients were clinically cured, 31.97% of them were clinically effective. There were 8 out of 122 patients appeared local side effects, and there were 2 out of 122 patients appeared systemic symptoms. Conclusion Dust mites specific desensitization therapy is an effective method for the dust allergic conjunctivitis.

关 键 词：变应性结膜炎 脱敏作用 治疗 免疫性 尘螨 

分 类 号：R765.210.5[医药卫生—耳鼻咽喉科]